Sökning: "Brain tumors"

Visar resultat 11 - 15 av 168 avhandlingar innehållade orden Brain tumors.

1. 11. Metabolomics and proteomics studies of brain tumors : a chemometric bioinformatics approach

   Författare :Lina Mörén; Henrik Antti; Anders Malmendal; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioblastoma; glioma; meningioma; metabolomics; proteomics; mass-spectrometry; biologisk kemi; biological chemistry;

   Sammanfattning : The WHO classification of brain tumors is based on histological features and the aggressiveness of the tumor is classified from grade I to IV, where grade IV is the most aggressive. Today, the correlation between prognosis and tumor grade is the most important component in tumor classification. LÄS MER

3. 12. Heparan Sulfate Proteoglycans in Brain Tumor Development

   Författare :Argyris Spyrou; Karin Forsberg Nilsson; Fredrik Johansson Swartling; Jöns Hilborn; John Couchman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; pediatric brain tumors; heparanase; NDST1; heparan sulfate proteoglycans; CD24; glycosaminoglycan mimetics; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Sammanfattning : Malignant brain tumors are aggressive neoplasms that remain challenging to treat in spite of their detailed molecular characterization. Both adults and children may suffer from brain tumors, which, if not lethal, can cause severe long-term and devastating side effects. LÄS MER

4. 13. Genetic and Epigenetic Variation in the Human Genome : Analysis of Phenotypically Normal Individuals and Patients Affected with Brain Tumors

   Författare :Cecilia De Bustos; Jan P. Dumanski; Joseph F. Costello; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; genetic variation; epigenetics; brain tumor; array-CGH; glioblastoma; ependymoma; microarray; methylation; Genetik; Genetics; Genetik;

   Sammanfattning : Genetic and epigenetic variation is a key determinant of human diversity and has an impact on disease predisposition. Single nucleotide polymorphisms (SNPs) and copy number polymorphisms (CNPs) are the main forms of genetic variation. The challenge is to distinguish normal variations from disease-associated changes. LÄS MER

5. 14. Experimental models of pediatric brain tumors. Establishment, immunophenotyping and clinical implications

   Författare :Emma Sandén; Neurokirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatric Brain Tumor; Experimental model; Immunotherapy; Immune monitoring; Medulloblastoma;

   Sammanfattning : Brain tumors are the most common solid tumors in children. Current treatment protocols fail in 25% of patients and are associated with significant long-term adverse effects in survivors. LÄS MER

7. 15. From Genes to Therapy : Modeling and Novel Therapeutic Strategies for Brain Tumors

   Författare :Matko Čančer; Fredrik Swartling; Lene Uhrbom; Suzanne J. Baker; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; Glioblastoma; MYCN; PDGF; Cancer Therapy; BET bromodomains; Temozolomide; Medicinsk vetenskap; Medical Science; Oncology; Onkologi;

   Sammanfattning : Medulloblastoma is the most common malignant pediatric brain tumor and is molecularly divided into four subgroups – WNT, SHH, Group 3 and Group 4. Two thirds of medulloblastoma patients survive, but survivors often suffer from severe, lifelong side-effects. The MYCN oncogene is deregulated in many medulloblastoma patients. LÄS MER