Sökning: "Bone fracture"

Visar resultat 21 - 25 av 180 avhandlingar innehållade orden Bone fracture.

1. 21. Metabolomics, body composition and fracture

   Författare :Rui Zheng; Karl Michaëlsson; Harri Sievänen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolomics; LC-MS; sample quality; cohort; body composition; fracture; Medicinsk vetenskap; Medical Science; Bioinformatics; Bioinformatik; Epidemiologi; Epidemiology; Orthopaedics; Ortopedi; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Sammanfattning : In this thesis, I evaluated the impact of pre-centrifugation sample management on the plasma metabolome, providing verification for the protocol used in a study where I applied metabolomics to better understand the role of body composition in fracture occurrence using a large population-based cohort.  In paper 1, I applied untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics analysis to plasma samples (n = 471) from healthy donors to predict and evaluate the effect of pre-centrifugation temperature and delay time on metabolomics data using a combination of random forest and generalized linear models. LÄS MER

3. 22. Genetic and Environmental Influences on Bone and Fractures

   Författare :Helene Wagner; Karl Michaëlsson; Håkan Melhus; Nancy Pedersen; Kristina Åkesson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heritability; twin study; osteoporotic fractures; vertebral fractures; balance; bone mineral density; bone area; bone markers; Orthopaedics; Ortopedi;

   Sammanfattning : Sweden and Norway have the worldwide highest incidence of osteoporotic fractures. As these fractures constitute a tremendous and growing problem, primary prevention is of great importance. The principal causes of an osteoporotic fracture are a fall and a fragile skeleton. LÄS MER

4. 23. Hip fractures : A biomechanical analysis of fracture strength prediction, prevention, and repair

   Författare :Joeri Kok; Avdelningen för Biomedicinsk teknik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Finite element; Bone cement; Femur; Fracture; Experimental mechanics; X-ray imaging;

   Sammanfattning : Due to the aging population, hip fracture incidence has been increasing over the past decades. Measurements of bone mineral density with dual energy X-ray absorptiometry are the gold standard for hip fracture risk assessment, where patients with a low bone density have a high risk of fracture. LÄS MER

5. 24. Diseases in the hip - Exploring risk for fracture and osteoarhritis

   Författare :Cecilie Hongslo Vala; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hip fracture; Femoral neck fracture; Trochanteric fracture; Osteoporosis; Osteoarthritis; Total hip replacement; Total knee replacement; Farmers; Homogamy; Assortative mating; Bereavement;

   Sammanfattning : Objective: Hip fracture is the most serious condition linked to low bone mass or osteoporosis, and Sweden has one of the highest incidences in the world. The proportion of elderly is increasing in the Swedish population and in the world, and with increased age comes increased incidence for both fragility fracture and osteoarthritis. LÄS MER

7. 25. Boning up on Vitamin D : Observational Studies on Bone and Health

   Författare :Greta Snellman; Karl Michaëlsson; Haakon Meyer; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vitamin D; fracture; BMD; assays; genes; mortality; cohort studies; Orthopaedics; Ortopedi;

   Sammanfattning : The primary function of vitamin D in humans is to maintain sufficient circulating calcium concentrations. Low vitamin D levels could result in excessive calcium resorption from bone. Vitamin deficiency may therefore decrease bone mineral density (BMD), resulting in an increased risk of fracture. LÄS MER