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Visar resultat 1 - 5 av 55 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Toxicometabolomics and biotransformation product screening in single zebrafish embryos

    Författare :Anton Ribbenstedt; Jonathan P. Benskin; Magnus Breitholtz; Elena Gorokhova; Emma Schymanski; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Non-target; REACH; Orbitrap; single embryo; zebrafish embryo; metabolism; high throughput; hydroxylation; glucuronidation; metabolite screening; phase I; phase II; pharmaceutical; structure elucidation; conjugation; propranolol; beta blocker; Non-targeted; toxicometabolomics; Orbitrap; single embryo; 3R; metabolomics; MoA; mode of action; zebrafish embryo; carbamazepine; biotransformation; Applied Environmental Science; tillämpad miljövetenskap;

    Sammanfattning : Over the last decade environmental agencies worldwide have escalated their work to phase out animal testing for the purposes of chemical regulation. Meanwhile the number of commercially available chemicals and the requirements for hazard assessments have both increased, creating a large need for substitution of traditional in vivo assays with in vitro tests. LÄS MER

  3. 2. Cryogels Based on Crosslinked Cells as Green Biocatalysts for Biotechnology

    Författare :Oksana Zaushitsyna; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Cells; Crosslinkers; PVA PEI; Immobilization; Biocatalysts; Biobased chemicals; Biotransformation; stress tolerance;

    Sammanfattning : Abstract Due to the finite nature of fossil resources and their environmental impact, such as greenhouse gases and climate change, the bio-based production of chemicals, materials and fuels is the subject of extensive research in industrial biotechnology. Biotransformation and fermentation are considered to be mild, “green” processes that make use of effective and reliable biocatalysts to provide bio-based chemicals. LÄS MER

  4. 3. Biotransformations of Turpentine Constituents : Oxygenation and Esterification

    Författare :Marica Lindmark-Henriksson; KTH; []
    Nyckelord :Picea abies; Pinaceae; Essential oils composition; Terpene alcohol; Hemiacetal; Hemiacetal ester; TMP-turpentine; Monoterpene; alpha-pinene; beta-pinene; Limonene; Verbenol; Pinocarveol; Borneol; Myrtenol; Suspension cell culture; Biotransformation; ;

    Sammanfattning : This thesis describes methods to obtain value–addedcompounds from TMP-turpentine obtained from the spruce, Piceaabies. The methodology focuses on biotransformations using twoapproaches: an oxygenation approach (i.e. oxygenation ofterpene hydrocarbons by cell cultures) and an esterificationapproach (i. LÄS MER

  5. 4. Occupational exposure to fluorinated ski wax

    Författare :Helena Nilsson; Jonathan W. Martin; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Perfluorinated; polyfluorinated; FIS; occupational exposure; ski wax; biotransformation; metabolism; fluorotelomer alcohol; fluorotelomer acid; aerosol; dust; UPLC MS-MS; GC MS-MS; Kemi; Chemistry;

    Sammanfattning : Per- and polyfluorinated substances (PFAS) are used in the production of ski wax to reduce the friction between the snow and the ski. In this occupational study of ski wax technicians’ exposure to PFAS and particulate aerosol we have collected whole blood (wb) (n =94), air (n =84) and aerosol (n =159) samples at World Cup events from 2007-2011. LÄS MER

  7. 5. Bio-based C-3 Platform Chemical: Biotechnological Production and -Conversion of 3-Hydroxypropionaldehyde

    Författare :Roya Rezaei; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Lactobacillus reuteri; 3-hydroxypropionic acid; biotransformation; Glycerol; 3-hydroxypropionaldehyde; In situ complexation;

    Sammanfattning : Demands for efficient, greener, economical and sustainable production of chemicals, materials and energy have led to development of industrial biotechnology as a key technology area to provide such products from bio-based raw materials from agricultural-, forestry- and related industrial residues and by-products. For the bio-based industry, it is essential to develop a number of building blocks or platform chemicals for C2-C6 chemicals and even aromatic chemicals. LÄS MER