Sökning: "Biophysical Characterisation"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Biophysical Characterisation.
1. Evolution and Binding Mechanisms of Intrinsically Disordered Proteins
Sammanfattning : Intrinsically disordered proteins (IDPs) make up a considerable fraction of the proteome in eukaryotic organisms. These proteins often act as hubs in interaction networks, harbouring multiple interaction with other proteins, and thus evolution has to walk a tightrope to accommodate new interactions while maintaining the previously established interactions. LÄS MER
2. Biophysical Characterisation of Macromolecules. Protein Folding and DNA Structure Determination
Sammanfattning : .... LÄS MER
3. Antibody-Fragments: Protein Engineering, Process Development, and their Application as Affinity Ligands
Sammanfattning : Monoclonal antibody (mAb) fragments have become the formats of choice for both biopharmaceuticals and ligands in analytical and preparative applications. Their smaller size enables additional advantages over full-length mAbs, such as improved tissue penetration, faster blood clearance for diagnostic applications, improved capacity, and enablement of multivalent formatting. LÄS MER
4. Apoptosis Regulation via the Mitochondrial Pathway : Membrane Response upon Apoptotic Stimuli
Sammanfattning : The aim of this thesis was the investigation of the mitochondrial response mechanisms upon apoptotic stimuli. The specific objectives were the biophysical characterization of membrane dynamics and the specific roles of lipids in the context of apoptotic regulation occurring at the mitochondrion and its complex membrane systems. LÄS MER
5. From cell populations to single cells - quantitative analysis of osmotic regulation in yeast
Sammanfattning : To date, interdisciplinary research is becoming increasingly popular because it combines the achievements of diverse disciplines, having the potential of providing a completely new angle to pertinent research problems. Using increasingly sophisticated tools allowed obtaining large sets of high resolution data but also created the challenge of using this information effectively and interpreting it in a reliable way. LÄS MER