Sökning: "Biomolecule interactions"
Visar resultat 16 - 20 av 21 avhandlingar innehållade orden Biomolecule interactions.
16. The role of RNA in prion aggregation and disease
Sammanfattning : As humanity evolved to witness an exceptionally high standard of living, Alzheimer’s, cancer and diabetes gradually replaced infections as the main limiting factors in longevity. It is both disturbing and captivating that such degenerative conditions are caused by the most ubiquitous biomolecule – the protein. LÄS MER
17. Förster Resonance Energy Transfer - from single molecule spectroscopy to imaging
Sammanfattning : During the last fifteen years several methods have been developed for probing biomolecules (DNA, RNA, proteins) one at a time. Among these methods fluorescence spectroscopy and in particular its many implementations for monitoring Förster Resonance Energy Transfer (FRET), have attracted much interest. LÄS MER
18. Folded polypeptide scaffolds for biosensor and biochip applications : design, synthesis, functionalisation and characterisation
Sammanfattning : This thesis describes the design, synthesis and evaluation of functional molecular units intended for use in biosensor and microarray applications. A flexible, synthetic helix-loop-helix polypeptide that dimerises to form four-helix bundles was used as a scaffold and was modified with affinity ligands and fluorescent probes to specifically bind a target biomolecule and report on this event in an integrated process. LÄS MER
19. Development of chemical biology tools for metabolomics analysis : Phase II modifications as a link between host and microbiota co-metabolism
Sammanfattning : Biomarker discovery is an extremely important field for early disease detection. New selective molecular markers are in high demand, as an earlier disease detection can lead to improved patient care. LÄS MER
20. Silicon Nanoribbon FET Sensors : Fabrication, Surface Modification and Microfluidic Integration
Sammanfattning : Over the past decade, the field of medical diagnostics has seen an incredible amount of research towards the integration of one-dimensional nanostructures such as carbon nanotubes, metallic and semiconducting nanowires and nanoribbons for a variety of bio-applications. Among the mentioned one-dimensional structures, silicon nanoribbon (SiNR) field-effect transistors (FET) as electro-chemical nanosensors hold particular promise for label-free, real-time and sensitive detection of biomolecules using affinity-based detection. LÄS MER