Sökning: "Biomembrane"

Visar resultat 16 - 19 av 19 avhandlingar innehållade ordet Biomembrane.

  1. 16. NMR studies on lipid-peptide co-aggregation between ganglioside-containing membranes and α-synuclein

    Författare :Simon Fridolf; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein aggregation; nuclear magnetic resonance spectroscopy; lipid membrane; ganglioside; alpha-synuclein;

    Sammanfattning : This topic of this thesis is how the presence of biomembrane molecules affect the behavior of a protein related to Parkinson’s disease in a simplified (compared to in the cell) model system.Lipids are fat molecules that make up the biological barriers in our body that control transport of essential molecules in and out of the cell and create an environment where membrane proteins can perform their functions. LÄS MER

  3. 17. Structural and Biochemical Characterizations of Three Potential Drug Targets from Pathogens

    Författare :Lu Lu; Sherry L Mowbray; Alwyn Jones; Christian Cambillau; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LepB; DXR; NDH-2; fosmidomycin; quinolinyl pyrimidine; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Sammanfattning : As antibiotic resistance of various pathogens emerged globally, the need for new effective drugs with novel modes of action became urgent. In this thesis, we focus on infectious diseases, e.g. LÄS MER

  4. 18. Development of NMR methods for studies of dynamics and structure : applications to motilin, Alzheimer β-peptide and ubiquitin

    Författare :Peter Damberg; Ad Bax; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biophysics; biofysik;

    Sammanfattning : NMR spin relaxation was used to study structure and dynamics of two biologically important peptides.The first case concerns the three-dimensional structure of the 22 amino acid residue peptide hormone motilin in the presence of SDS micelles, which mimic a biomembrane environment. LÄS MER

  5. 19. Tethered Lipid Vesicles as Nanoscale Sensor Elements

    Författare :Seyed Tabaei; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; aquaglyceroporin; lipid vesicles; total internal reflection fluorescence TIRF microscopy; cell membrane; aquaporin; pore formation; surface plasmon resonance SPR ; phospholipase A2; antiviral peptide; lipid bilayer; biosensing; microfluidics;

    Sammanfattning : The primary aim of this thesis work has been to explore and advance the potential of surface tethered lipid vesicles as a platform for studying in particular the following three biomembrane-related processes: trans-membrane transport, membrane-peptide interactions and the activity of membrane active enzymes. First, a method based on surface plasmon resonance (SPR) spectroscopy was developed for studying passive diffusion processes as well as the membrane-protein mediated transport of small non electrolyte molecules across lipid bilayers. LÄS MER