Sökning: "Biomedicinsk strålningsvetenskap"

Visar resultat 6 - 10 av 34 avhandlingar innehållade orden Biomedicinsk strålningsvetenskap.

  1. 6. Molecular Imaging of HER2 Expression using Synthetic Affibody Molecules : Design, Synthesis and Biological Evaluation

    Författare :Thuy Tran; Vladimir Tolmachev; Uwe Haberkorn; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

    Sammanfattning : Molecular imaging is an emerging multidisciplinary field that addresses the visualisation of diseases at the cellular and molecular levels. This thesis focuses on the development of a synthetic Affibody molecule-based imaging tracer for the detection of HER2 expression in malignant tumours. LÄS MER

  3. 7. Radiation response in human cells : DNA damage formation, repair and signaling

    Författare :Ann-Sofie Gustafsson; Bo Stenerlöw; Andrzej Wojcik; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionizing radiation; heat-labile sites; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Ionizing radiation induces a range of different DNA lesions. In terms of mutation frequency and mammalian cell survival, the most critical of these lesions is the DNA double-strand break (DSB). DSB left unrepaired or mis-repaired may result in chromosomal aberrations that can lead to permanent genetic changes or cell death. LÄS MER

  4. 8. Development of Affibody molecules for radionuclide molecular imaging and therapy of cancer

    Författare :Hadis Honarvar; Vladimir Tolmachev; Raymond M. Reilly; Uppsala universitet; []
    Nyckelord :Affibody molecules; HER2; Molecular imaging; Radionuclide targeted therapy; Radionuclide molecular imaging; Labeling chemistry; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Affibody molecules are a promising class of scaffold-based targeting proteins for radionuclide-based imaging and therapy of cancer. This thesis work is based on 5 original research articles (papers I-V), which focus on optimization of molecular design of HER2-binding Affibody variants for high contrast imaging of this predictive biomarker as well as development of Affibody molecules suitable for radionuclide-based targeted therapies. LÄS MER

  5. 9. Searching for Synergy : Radiosensitization of 177Lu-DOTATATE

    Författare :Sara Lundsten; Marika Nestor; Hanna Björkelund; Katarina Edwards; Julie Nonnekens; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; targeted radionuclide therapy; radiosensitization; p53; MDM2 MDM4 inhibition; HSP90; drug synergy; drug delivery; lipid nanoparticles; lipodisks; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Cancers presents a major health challenge, and there is a pressing need to develop new therapeutic strategies. Surgery, chemotherapy and radiation are the most commonly used treatments for cancer today. Radiation can be given as targeted radionuclide therapy (TRT), i.e. LÄS MER

  7. 10. Precision medicine and targeted therapy : Turning the tables on cancer

    Författare :Anja Mortensen; Marika Nestor; Gregory Adams; Uppsala universitet; []
    Nyckelord :p53 cancers; PM2; radiosensitization; radio-immunotherapy; MDM2 X inhibition; combination therapy; targeted radionuclide therapy; CD44v6; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : An extended understanding of the molecular characteristics of cancer has led to a revolution within the field of precision medicine. This thesis explores the utilization of two targets for precision medicine, namely, CD44v6 and murine double-minute 2 and X (MDM2/X). LÄS MER