Sökning: "Biomedicin"

Visar resultat 21 - 25 av 523 avhandlingar innehållade ordet Biomedicin.

  1. 21. Characterisation of Neisseria meningitidis from a virulence and immunogenic perspective that includes variations in novel vaccine antigens

    Författare :Susanne Jacobsson; Hans Fredlund; Per Olcén; Paula Mölling; Elisabeth Wedege; Örebro universitet; []
    Nyckelord :Neisseria meningitidis; meningococcal disease; risk factors; vaccine; genome-derived neisserial antigens GNA ; polymerase chain reaction PCR ; sequencing; MEDICINE; MEDICIN; Medicin; Medicine; Biomedicin; Biomedicine;

    Sammanfattning : Neisseria meningitidis, also referred to as meningococcus, is a Gram-negative diplococcal bacterium best known as an important cause of meningitis and septicaemia worldwide. Meningococcal disease is a rare but life-threatening illness that may progress to death despite optimal medical care including appropriate antibiotic therapy. LÄS MER

  3. 22. Inflammation in atherosclerosis

    Författare :Ken Jatta; Allan Sirsjö; Michael D. Menger; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atherosclerosis; chemokine; cytokine; inflammation; Lipopolysacchride; Carotid lesion; interleukin; viperin Cig5; smooth muscle cells; Cardiovascular medicine; Kardiovaskulär medicin; MEDICINE; MEDICIN; Biomedicin; Biomedicine;

    Sammanfattning : Consequences of atherosclerosis may result in a number of diseases of the cardiovascular system that represent serious health problems and major causes of morbidity and mortality worldwide. Although it is initially considered as disease of fibro-lipid and thrombus deposition in the arterial wall, it also involves an ongoing inflammatory response. LÄS MER

  4. 23. Monocyte and Neutrophil Inflammatory Responses to the Periodontopathogen Porphyromonas gingivalis

    Författare :Kartheyaene Jayaprakash; Torbjörn Bengtsson; Allan Sirsjö; Hazem Khalaf; Anders Johansson; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Monocytes; Neutrophils; Porphyromonas gingivalis; Gingipains; Biomedicin; Biomedicine;

    Sammanfattning : Periodontitis is one of the most common adult infections. Duing bacteremia in healthy individuals or patients with chronic periodontitis, a number of oral bacteria such as Porphyromonas gingivalis encounter inflammatory cells in the blood eg. platelets, neutrophils and monocytes. LÄS MER

  5. 24. Amino acid transport and receptor binding properties in neuropsychiatric disorders using the fibroblast cell model

    Författare :Jessica Johansson; Nikolaos Venizelos; Lars Oreland; Örebro universitet; []
    Nyckelord :Fibroblasts; Bipolar disorder; ADHD; Tyrosine; Tryptophan; Alanine; Transport; mAChRs; Biomedicin; Biomedicine;

    Sammanfattning : Altered transport of the catecholamines and serotonin precursor amino acids tyrosine and tryptophan, might be one explanation for the dysfunctional neurotransmission implicated in the pathophysiology of bipolar disorder and Attention Deficit/Hyperactivity Disorder (ADHD). In previous studies, an altered amino acid transport has been found in schizophrenia and autism, when using the fibroblast cell model. LÄS MER

  7. 25. Structural / functional studies on human alkaline phosphatases

    Författare :Alexey Kozlenkov; Jose-Luis Millan; Hans Jörnvall; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; mutagenesis; enzyme kinetics; computer modeling; crystallography; natural substrates; uncompetitive inhibition; isozymes; gene families; Biomedicin; Microbiology; Mikrobiologi; medicinsk genetik; Medical Genetics;

    Sammanfattning : The recent elucidation of the three-dimensional structure of human placental alkaline phosphatase (PLAP) has enabled me to perform structural studies aimed at characterizing the properties of human PLAP and tissue-nonspecific AP (TNAP) as paradigms for mammalian APs in general, using site-directed mutagenesis, protein expression, kinetic analysis and computer modeling. In Paper I, we found that a single critical E429G substitution explains the difference in stability and kinetics between the common allelic variants of PLAP and the D allozyme. LÄS MER