Sökning: "Biomedicin"

Visar resultat 16 - 20 av 523 avhandlingar innehållade ordet Biomedicin.

  1. 16. Single-chain antibody construction and functional mapping of the monoclonal antibody TS1 : Its interaction with the antigen and the anti-idiotype

    Författare :Patrik Holm; Birgitta Sundström; Per-Åke Nygren; Karlstads universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chemistry; Kemi; Chemistry; Kemi; Biomedicin; Biomedical Laboratory Science;

    Sammanfattning : The aims of this study are to synthesize and produce a single-chain antibody (scFv) of the anti-cytokeratin 8 monoclonal IgG antibody TS1 and to functionally map amino acid residues important for the interaction with its antigen and the anti-idiotypic antibody TS1. The TS1 antibody has been shown to be effective in binding cytokeratin 8 (CK8) expressed in tumors in vivo and is proposed to be useful in immunotargeting and/or immunotherapy. LÄS MER

  3. 17. Telomere analysis of normal and neoplastic hematopoietic cells : studies focusing on fluorescence in situ hybridization and flow cytometry

    Författare :Magnus Hultdin; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; telomere; telomerase; fluorescence in situ hybridization; flow cytometry; flow-FISH; replication timing; chronic lymphocytic leukemia; immunoglobulin gene; prognosis; Biomedicin; Microbiology; Mikrobiologi; Medical Cell Biology; medicinsk cellbiologi;

    Sammanfattning : The telomeres are specialized structures at the end of the chromosomes composed of the repeated DNA sequence (TTAGGG)n and specific proteins bound to the DNA. The telomeres protect the chromosomes from degradation and end to end fusions. LÄS MER

  4. 18. Cardiovascular risk factors in children

    Författare :Anita Hurtig Wennlöf; Örebro universitet; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICINE; MEDICIN; Biomedicin; Biomedicine; Accelerometry; blood pressure; cardiorespiratory fitness; ergometer bike; glucose; insulin; lipids; physical activity.;

    Sammanfattning : .... LÄS MER

  5. 19. Cell responses in infected and cystic fibrosis respiratory epithelium

    Författare :Rashida Hussain; Godfried M . Roomans; Maria Björkqvist; Ferenc Karpati; Hans Kollberg; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; airway epithelial cells; cystic fibrosis; bacterial infection; CFTR; ENaC; chloride transport; intracellular calcium; P. aeruginosa internalization; Biomedicin; Biomedicine;

    Sammanfattning : Respiratory Epithelium. Örebro Studies in Medicine 99. Cystic fibrosis (CF) is caused by a mutation in a cAMP-activated chloride (Cl-) channel (CFTR). Mortality and morbidity in CF is mainly due to the deregulated responses of the airway epithelial cells. LÄS MER

  7. 20. Plasminogen activator inhibitor type-1 : structure-function studies and its use as a reference for intramolecular distance measurements

    Författare :Peter Hägglöf; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; PAI-1 serpin RCL complex formation DDEM Intramolecular distance; Biomedicin; Microbiology; Mikrobiologi; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Inhibitors belonging to the serpin (serine protease inhibitor) family control proteases involved in various physiological processes. All serpins have a common tertiary structure based on the dominant b-sheet A, but they have different inhibitory specificity. LÄS MER