Sökning: "Biomarker"

Visar resultat 16 - 20 av 777 avhandlingar innehållade ordet Biomarker.

1. 16. Significance of Wilms’ tumor gene 1 as a biomarker in acute leukemia and solid tumors

   Författare :Charlotta Andersson; Eva Lundin; Aihong Li; Andreas Jonsson; Xingru Li; David M. Loeb; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wilms’ tumor gene 1; biomarker; leukemia; renal cell carcinoma; ovarian carcinoma; Clinical Chemistry; klinisk kemi; patologi; Pathology;

   Sammanfattning : Wilms’ tumor gene 1 (WT1) is a zinc finger transcriptional regulator with crucial functions in embryonic development. Originally WT1 was described as a tumor suppressor gene, but later studies have shown oncogenic properties of WT1 in a variety of tumors. Because of its dual functions in tumorigenesis, WT1 has been described as a chameleon gene. LÄS MER

3. 17. Breast Cancer Biomarkers with Clinical Relevance Identified by Massively-parallel DNA and RNA Sequencing

   Författare :Malin Dahlgren; Translational Oncogenomics; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; DNA sequencing; RNA sequencing; Metastasis; Biomarker; Estrogen receptor alpha; Estrogen receptor beta; ESR1; ESR2; Breast cancer; DNA sequencing; RNA sequencing; metastasis; biomarker; Estrogen receptor alpha; Estrogen receptor beta; ESR1; ESR2;

   Sammanfattning : Women have a 10% lifetime risk of developing breast cancer, and the disease has surpassed lung cancer as the most frequently diagnosed type of cancer in the world. Breast cancer originates in the epithelial cells of the mammary gland and tumor cells have undergone a series of genetic and phenotypic changes that confer tumor promoting properties. LÄS MER

4. 18. Systemic sclerosis. Novel molecular and epidemiological features of disease

   Författare :Kristofer Andréasson; Reumatologi och molekylär skelettbiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic sclerosis; fibrosis; COMP; calprotectin; biomarker; gastrointestinal;

   Sammanfattning : Systemic sclerosis (SSc) is a systemic rheumatic disease with significant mortality and morbidity. Different estimations of disease prevalence and incidence have been presented from various parts of the world. LÄS MER

5. 19. Biomarkers for Better Understanding of the Pathophysiology and Treatment of Chronic Pain : Investigations of Human Biofluids

   Författare :Anne-Li Lind; Torsten Gordh; Masood Kamali-Moghaddam; Jonas Bergquist; Eva Kosek; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chronic pain; neuropathic pain; lumbar radicular pain; amyotrophic lateral sclerosis; radiculopathy; fibromyalgia; pathophysiology; spinal cord stimulation; mechanism of action; disc herniation; cerebrospinal fluid; plasma; biomarker; human; protein; chemokines; cytokines; inflammation; neuroinflammation; mass spectrometry; proximity ligation assay; proximity extension assay; antibody suspension bead array; protein profiling; molecular medicine; personalized medicine; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Chronic pain affects 20 % of the global population, causes suffering, is difficult to treat, and constitutes a large economic burden for society. So far, the characterization of molecular mechanisms of chronic pain-like behaviors in animal models has not translated into effective treatments. LÄS MER

7. 20. CSF biomarkers reflecting beta-amyloid and axonal pathology in Alzheimer's disease and related conditions

   Författare :Niklas Mattsson; Göteborgs universitet; []
   Nyckelord :Alzheimer s disease; biomarker; cerebrospinal fluid; beta-amyloid; axonal; Niemann-Pick type C; neuroborreliosis;

   Sammanfattning : Cerebrospinal fluid (CSF) biomarkers may be used to identify and monitor pathological processes in the central nervous system. CSF biomarkers in Alzheimer’s disease (AD) include β-amyloid 42 (Aβ42), total-tau (T-tau) and phosphorylated-tau (P-tau), reflecting brain amyloid, axonal and tangle pathology, respectively. LÄS MER