Sökning: "Biology with specialization in Molecular Cell Biology"

Visar resultat 16 - 20 av 101 avhandlingar innehållade orden Biology with specialization in Molecular Cell Biology.

1. 16. Tumor-stroma interactions in hepatocellular carcinoma

   Författare :Nataša Pavlović; Femke Heindryckx; Jessica Maiers; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatocellular carcinoma; fibrosis; endoplasmic reticulum stress; unfolded protein response; platelets; P2Y12; Molekylär cellbiologi; Molecular Cellbiology; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : Hepatocellular carcinoma (HCC), a highly deadly primary liver cancer with a rising global incidence and limited therapeutic options, is characterized by a vicious cross-talk between the tumor and its surrounding hepatic stroma. The stromal environment, consisting of hepatic stellate cells (HSC), endothelial cells, resident and infiltrating macrophages and other immune cells, platelets and extracellular matrix (ECM) components, actively contributes to creating an ideal niche for tumor proliferation and invasiveness. LÄS MER

3. 17. Generating Dendritic Cells by Direct Cell Reprogramming. Merging cellular reprogramming with immunology towards the development of novel cancer immunotherapies

   Författare :Fábio Fiúza Rosa; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dendritic Cell; Direct Cell Reprogramming; Single-cell analysis; Immunotherapy;

   Sammanfattning : Cell fate reprogramming towards pluripotency or alternative somatic cell-types has highlighted the plasticity of adult somatic cells, providing new technologies to generate desired cell types for tissue repair or for disease modeling. There is momentum to bring these concepts to immunology by specifying unique immune cellular identities that set in motion immune responses. LÄS MER

4. 18. Morphological changes in mycobacteria

   Författare :Malavika Ramesh; Leif A. Kirsebom; Anders Løbner-Olesen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mycobacteria; pleomorphism; dnaK_3; microaerobic condition; Morphology; oxygen deprivation; spore-like cells; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : Morphological variations at different stages and conditions of growth has been observed frequently in various mycobacteria. Despite years of research, the molecular basis of such variations is still not clear and requires further elucidation. LÄS MER

5. 19. Membrane lipids and their transfer proteins in β-cells

   Författare :Beichen Xie; Olof Idevall-Hagren; Anders Tengholm; Jen Liou; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ca2 ; PKC; E-Syt1; TMEM24; ER-PM contact; PI 4; 5 P2; phosphoinositides; β-cell; insulin; optogenetics; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Sammanfattning : Insulin secretion from β-cells is essential for glucose homeostasis and is often dysregulated in diabetes. Intracellular Ca2+ and membrane lipids cooperate to control insulin secretion with high spatial and temporal precision. LÄS MER

7. 20. Role of Cell-cell Interactions and Palmitate on β-cells Function

   Författare :Azazul Islam Chowdhury; Peter Bergsten; Gunilla Westermark; Peter Jones; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolism; PI3K; Pseudoislets; Human islets; SOCS; PIAS; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : The islets of Langerhans secrets insulin in response to fluctuations of blood glucose level and efficient secretion requires extensive intra-islet communication. Secretory failure from islets is one of the hallmark in progression of type 2 diabetes. LÄS MER