Sökning: "Biology with specialization in Molecular Biology"

Visar resultat 6 - 10 av 179 avhandlingar innehållade orden Biology with specialization in Molecular Biology.

  1. 6. Evolution of cellular complexity and other remarkable features in Gemmataceae : Complex bacterial lineages defy prokaryotic trends

    Författare :Mayank Mahajan; Siv G. E. Andersson; James O. McInerney; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Molecular evolution; Planctomycetes; Gemmataceae; functional organization; signalling; protein interaction; peptidoglycan; membranes; cell division; radiation tolerance; Pfam; SCOP; comparative genomics; protein architecture; domain shuffling and orthologous clustering; Bioinformatics; Bioinformatik; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : Bacteria of the family Gemmataceae belong the phylum Planctomycetes and are remarkable because of their complex cellular architectures, previously considered to be traits exclusive to eukaryotes. This thesis provides clues to the atypical cell envelope, the enhanced radiotolerance and the amazing cellular complexity of these bacteria. LÄS MER

  3. 7. Long Noncoding RNA Mediated Regulation of Imprinted Genes

    Författare :Faizaan Mohammad; Chandrasekhar Kanduri; Kristian Helin; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Genomic imprinting; noncoding RNA; epigenetics; chromatin; DNA methylation; Developmental biology; Utvecklingsbiologi; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : Genomic imprinting is an epigenetic phenomenon that causes a subset of mammalian genes to be expressed from only one allele in a parent-of-origin manner. The defects in the imprinting regulation result in disorders that affect development, growth and metabolism. LÄS MER

  4. 8. Mechanisms in Tendon Healing : Pain, Biomarkers and the Role of Mast Cells

    Författare :Abdul Alim; Magnus Peterson; Gunnar Pejler; Per Kristiansson; Paul W. Ackermann; Gustav Andersson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tendon Healing; Pain; Biomarkers; Mast Cells; Inflammation; Microdialysis; Neurotransmitters; Glutamate Receptors; Procollagen; Transcriptional factors; Biology with specialization in Molecular Immunology; Biologi med inriktning mot molekylär immunologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Neuroscience; Neurovetenskap;

    Sammanfattning : Tendon injuries and tendinopathy are common disorders, but the underlying mechanisms are not well understood. The overall aim of this thesis was to better understand the mechanisms underlying tendon healing, pain, and inflammation. LÄS MER

  5. 9. New Paradigms in GPCR Drug Discovery : Structure Prediction and Design of Ligands with Tailored Properties

    Författare :Mariama Jaiteh; Jens Carlsson; David E Gloriam; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G Protein-Coupled Receptor; Molecular Docking; Virtual Screening; Homology Modeling; Molecular Dynamics Simulation; Chemical Library; Functionally Selective Ligand; Polypharmacology; Dimerization; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. LÄS MER

  7. 10. Modelling Approaches to Molecular Systems Biology

    Författare :David Fange; Måns Ehrenberg; Johan Elf; Terence Hwa; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; stochastic reaction-diffuion kinetics; antibiotic drugs; efflux pumps; amino acid biosynthesis; Min-system; rRNA operon; transcription; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : Implementation and analysis of mathematical models can serve as a powerful tool in understanding how intracellular processes in bacteria affect the bacterial phenotype. In this thesis I have implemented and analysed models of a number of different parts of the bacterium E. coli in order to understand these types of connections. LÄS MER