Sökning: "Bioinformatik och systembiologi"
Visar resultat 11 - 15 av 247 avhandlingar innehållade orden Bioinformatik och systembiologi.
11. Prediction, modeling, and refinement of protein structure
Sammanfattning : Accurate predictions of protein structure are important for understanding many processes in cells. The interactions that govern protein folding and structure are complex, and still far from completely understood. However, progress is being made in many areas. Here, efforts to improve the overall quality of protein structure models are described. LÄS MER
12. Machine Learning Enabled Functional Discovery in Yeast Systems Biology
Sammanfattning : Saccharomyces cerevisiae is a well-studied organism, yet roughly 20 percent of its proteins remain poorly characterized. Recent studies also seem to indicate that the pace of functional discovery is slow. LÄS MER
13. Two Optimization Problems in Genetics : Multi-dimensional QTL Analysis and Haplotype Inference
Sammanfattning : The existence of new technologies, implemented in efficient platforms and workflows has made massive genotyping available to all fields of biology and medicine. Genetic analyses are no longer dominated by experimental work in laboratories, but rather the interpretation of the resulting data. LÄS MER
14. Computational discovery of antibiotic resistance genes and their horizontal transfer
Sammanfattning : Antibiotic resistance is increasing among clinical infections and represents one of the most serious threats to public health. Pathogens often become resistant by acquiring mobile antibiotic resistance genes (ARGs) via horizontal gene transfer (HGT). LÄS MER
15. Bioinformatics mining for disease causing mutations : using the dog genome as a model for human disease
Sammanfattning : Humans and dogs share many common diseases, and it has been shown that the identification of mutations that cause disease in dogs can help unravel the genetic basis for a similar disease in humans. Mapping of traits and disease in dogs is not a new idea, but the sequencing of the whole dog genome, the creation of a dense SNP maps followed by the development of SNP arrays for high throughput genotyping has led to new facilitated mapping procedures. LÄS MER