Sökning: "Bioinformatik och systembiologi"

Visar resultat 1 - 5 av 160 avhandlingar innehållade orden Bioinformatik och systembiologi.

  1. 1. Robust inference of gene regulatory networks System properties, variable selection, subnetworks, and design of experiments

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Torbjörn E. M. Nordling; KTH.; [2013]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; network inference; reverse engineering; variable selection; model selection; feature selection; subset selection; system identification; system theory; network theory; subnetworks; design of experiments; perturbation experiments; gene regulatory networks; biological networks;

    Sammanfattning : In this thesis, inference of biological networks from in vivo data generated by perturbation experiments is considered, i.e. deduction of causal interactions that exist among the observed variables. Knowledge of such regulatory influences is essential in biology. LÄS MER

  2. 2. Development of Computational Methods for Cancer Research: Strategies for closing the feedback loop in omics workflows

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Ufuk Kirik; Lunds universitet.; Lund University.; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cancer; proteome profiling; bioinformatics; pathway analysis; mass spectrometry; Quantitative proteomics;

    Sammanfattning : Popular Abstract in Swedish Den mänskliga kroppen är ett komplext maskineri med en rad olika reglersystem och kontrollmekanismer. Flera grenar av modern biomedicinsk forskning riktar sig mot olika nivåer av detta komplexa maskineri. LÄS MER

  3. 3. Tumour evolution and novel biomarkers in breast cancer

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Jana Biermann; Göteborgs universitet.; Gothenburg University.; Göteborgs universitet.; Gothenburg University.; [2019]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; gene signature; molecular biomarkers; tumour clonality; genomic instability; Swedish haemangioma cohort;

    Sammanfattning : Several gene signatures have been proposed in the past two decades to improve outcome prediction for breast cancer patients and to guide treatment decisions. Current treatment guidelines, however, primarily focus on established clinicopathological features. LÄS MER

  4. 4. Rule-based Models of Transcriptional Regulation and Complex Diseases Applications and Development

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Susanne Bornelöv; Uppsala universitet.; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Histone modification; Transcription factor; Transcriptional regulation; Next-generation sequencing; Feature selection; Machine learning; Rule-based classification; Asthma; Allergy; Bioinformatik; Bioinformatics;

    Sammanfattning : As we gain increased understanding of genetic disorders and gene regulation more focus has turned towards complex interactions. Combinations of genes or gene and environmental factors have been suggested to explain the missing heritability behind complex diseases. LÄS MER

  5. 5. Genetic factors affecting pregnancy duration in humans

    Detta är en avhandling från Gothenburg : University of Gothenburg

    Författare :Jonas Bacelis; Göteborgs universitet.; Gothenburg University.; [2018]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genomics; GWAS; Mendelian randomization; causal inference; preterm birth; pregnancy; gestation; height; text mining;

    Sammanfattning : This thesis investigates the mechanisms behind human pregnancy duration. Too short gestation is a direct cause of perinatal, neonatal, and infant mortality. Deviation from normal pregnancy length is also associated with a child's morbidity, even in the adulthood. LÄS MER