Sökning: "Biofysik"
Visar resultat 6 - 10 av 683 avhandlingar innehållade ordet Biofysik.
6. Biophysical studies of membrane interacting peptides derived from viral and Prion proteins
Sammanfattning : This thesis focuses on peptides derived from the Prion, Doppel and Influenza haemagglutinin proteins in the context of bilayer interactions with model membranes and live cells. The studies involve spectroscopic techniques like fluorescence, fluorescence correlation spectroscopy (FCS), circular and linear dichroism (CD and LD), confocal fluorescence microscopy and NMR. LÄS MER
7. Structural and functional studies of biomolecules with NMR and CD spectroscopy
Sammanfattning : Experimentally derived biomolecular structures were determined by Nuclear Magnetic Resonance (NMR). The properties of selected peptides and proteins in solution and in membrane mimicking micelles were observed by circular Dichroism (CD), mass spectrometry (MS), and other spectroscopic techniques. LÄS MER
8. Spectroscopic studies of nucleic acid structure and dynamics : including effects of metal ions and ligands
Sammanfattning : .... LÄS MER
9. A biophysical study of nucleic acid interactions with analogues and drugs
Sammanfattning : work presented in this thesis concerns studies on the physicochemical nature of interactions between nucleic acids and small ligands. The outcome of such studies can yield insights at a molecular level into the physiological mechanisms of action of biologically active nucleic-acid binding molecules. LÄS MER
10. Protein Folding and DNA Origami
Sammanfattning : In this thesis, the folding process of the de novo designed polypeptide chignolin was elucidated through atomic-scale Molecular Dynamics (MD) computer simulations. In a series of long timescale and replica exchange MD simulations, chignolin’s folding and unfolding was observed numerous times and the native state was identified from the computed Gibbs free-energy landscape. LÄS MER
