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  1. 1. Biophysical studies of cell-penetrating peptides and of the RNR inhibitor Sml1

    Författare :Elsa Bárány-Wallje; Astrid Gräslund; Joachim Seelig; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptides; transportan; bicelles; Sml1; Biophysics; Biofysik; Biophysics; biofysik;

    Sammanfattning : Several short peptides, so called cell-penetrating peptides, have the capability to transport large hydrophilic cargos through the cell membrane. The objective is to use these peptides as drug carriers and thereby enhance the uptake of drugs into cells.Three different cell-penetrating peptides are characterized in this thesis. LÄS MER

  3. 2. Structure and Dynamics of Membrane Associated Peptides

    Författare :Henrik Biverståhl; Lena Mäler; Charles R. Sanders; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biophysics; Biofysik; Biophysics; biofysik;

    Sammanfattning : The peptide-membrane interaction is a key element for many biological functions, from cell signaling to cell internalization. In this thesis the peptide-membrane interaction of six different peptides have been studied with respect to their structure, membrane location and dynamics with spectroscopic methods. LÄS MER

  4. 3. Large-scale prediction of protein subcellular localization : sequence-based methods and applications

    Författare :Olof Emanuelsson; Alfonso Valencia; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biophysics; Biofysik; Biochemistry; Biokemi; Biophysics; biofysik;

    Sammanfattning : .... LÄS MER

  5. 4. Spectroscopic studies of dynorphin neuropeptides and the amyloid beta-peptide : The consequences of biomembrane interactions

    Författare :Loïc Hugonin; Astrid Gräslund; Bernard Lebleu; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biophysics; Biofysik; Biophysics; biofysik;

    Sammanfattning : Dynorphin A, dynorphin B and big dynorphin are endogenous opioid neuropeptides. They play an important role in a wide variety of physiological functions such as regulation of pain processing and memory acquisition. Such actions are generally mediated through the κ-receptors. LÄS MER

  7. 5. Experimental studies of proton translocation reactions in biological systems : Electrogenic events in heme-copper oxidases

    Författare :Håkan Lepp; Peter Brzezinski; Thomas Nilsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; heme-copper oxidase; cytochrome c oxidase; nitric oxide reductase; cbb3-type oxidase; proton pumping; uncoupling; charge-transfer; electrogenic event; flow-flash; Biophysics; Biofysik; Biophysics; biofysik;

    Sammanfattning : Terminal heme-copper oxidases (HCuOs) are transmembrane proteins that catalyze the final step in the respiratory chain - the reduction of O2 to H2O, coupled to energy conservation by generation of an electrochemical proton gradient. The most extensively investigated of the HCuOs are the aa3-type oxidases, to which cytochrome c oxidase (CytcO) belongs, which uses energy released in the O2-reduction for proton pumping. LÄS MER