Sökning: "Bioassay"
Visar resultat 1 - 5 av 56 avhandlingar innehållade ordet Bioassay.
1. Bioassay analysis of dioxin-like compounds : response interactions and environmental transformation of Ah receptor agonists
Sammanfattning : Dioxin-like compounds mediate their toxicity by binding to the aryl hydrocarbon receptor (AhR) and through this receptor a cascade of biochemical and toxic events are triggered. Mechanism-specific dioxin bioassays utilise the AhR coupled induction of endogenous CYP1A proteins or reporter gene systems for detection of dioxin-like compounds and other AhR ligands. LÄS MER
2. Development of Protein Microarray Chip Technology: An Outlook towards Proteomics and Diagnostics
Sammanfattning : One attractive method for monitoring biomolecular interactions in a highly parallel fashion is the use of microarrays. Microarrays can be applied for screening proteins which makes it an attractive tool in clinical diagnostics, drug discovery studies and basic protein research; even though many methodological challenges and ones relating to the quality control of microarrays still need to be solved. LÄS MER
3. Physico-chemical characteristics and quantitative structure-activity relationships of PCBs
Sammanfattning : The polychlorinated biphenyls (PCBs) comprise a group of 209 congeners varying in the number of chlorine atoms and substitution patterns. These compounds tend to be biomagnified in foodwebs and have been shown to induce an array of effects in exposed organisms. LÄS MER
4. Characterization of PAH-contaminated soils focusing on availability, chemical composition and biological effects
Sammanfattning : The risks associated with a soil contaminated by polycyclic aromatic hydrocarbons (PAHs) are generally assessed by measuring individual PAHs in the soil and correlating the obtained amounts to known adverse biological effects of the PAHs. The validity of such a risk estimation is dependent on the presence of additional compounds, the availability of the compounds (including the PAHs), and the methods used to correlate the measured chemical data and biological effects. LÄS MER
5. Use of phytometers for evaluating ecological restoration
Sammanfattning : The increase in ecological restoration can be attributed to valuation of healthyecosystems and concerns for future climate changes. Freshwaters belong among theglobally most altered ecosystems and are restored to counteract human impacts. LÄS MER