Sökning: "Biliary excretion"

Visar resultat 11 - 14 av 14 avhandlingar innehållade orden Biliary excretion.

1. 11. Biopharmaceutical investigations of doxorubicin formulations used in liver cancer treatment : Studies in healthy pigs and liver cancer patients, combined with pharmacokinetic and biopharmaceutical modelling

   Författare :Ilse R Dubbelboer; Hans Lennernäs; Erik Sjögren; Hartmut Derendorf; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug delivery system; in vivo release; PBPK modelling; hepatocellular carcinoma; doxorubicin; transarterial chemoembolization; drug disposition; Biofarmaci; Biopharmaceutics; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : There are currently two types of drug formulation in clinical use in the locoregional treatment of intermediate hepatocellular carcinoma (HCC). In the emulsion LIPDOX, the cytostatic agent doxorubicin (DOX) is dissolved in the aqueous phase, which is emulsified with the oily contrast agent Lipiodol® (LIP). LÄS MER

3. 12. Steroids and bile acids in intrahepatic cholestasis of pregnancy : effects of treatment with ursodeoxycholic acid

   Författare :Ling-Jie Meng; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : A method permitting simultaneous analysis of individual steroid hormone metabolites and bile acids in different forms of conjugation in serum and urine was established. Total bile acids and neutral steroids were extracted from human serum or urine with octadecylsilane-bonded silica, separated into different groups of conjugates by anion-exchange chromatography and analyzed by fast atom bombardment mass spectrometry. LÄS MER

4. 13. Volume imaging of the abdomen : three-dimensional visualisation of tubular structures in the body with CT and MRI

   Författare :Anders Persson; Örjan Smedby; Håkan Ahlström; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : The overwhelming amount of image-based information in modem medicine makes it crucial to develop methods to handle and analyze images and make them comprehensible for users. The aim of this thesis was to study the radiological practice of three-dimensional (3D) visualization of tubular structures in the body with CT and MRI. LÄS MER

5. 14. Pharmacokinetics - Effect Relations of Glibenclamide and its Metabolites in Humans

   Författare :Tony S Rydberg; Institutionen för hälsovetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; renal insufficiency.; insulin; glucose; non-insulin dependent; diabetes mellitus; pharmacodynamic modelling; pharmacodynamics; pharmaco-kinetics; HPLC method; Glibenclamide; sulphonylurea; metabolites; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Sammanfattning : Glibenclamide (Gb) is the most commonly employed sulphonylurea worldwide for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). There has been uncertainty concerning its pharmacokinetics (PK) and pharmacodynamics (PD). LÄS MER