Sökning: "Beta-cell autoimmunity"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden Beta-cell autoimmunity.

  1. 1. Autoantibodies as markers of beta-cell autoimmunity in children

    Författare :Hanna Holmberg; Johnny Ludvigsson; Mona Landin-Olsson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Autoantibodies; Beta-cell autoimmunity; Children; Breast-feeding; HLA haplotypes; Insulin gene; Paediatric medicine; Pediatrisk medicin;

    Sammanfattning : Type 1 diabetes (T1D) is a chronic disease caused by destruction of the insulin producing beta-cells in the pancreas. The incidence of T1D has increased rapidly, especially in the Western world and among young children. LÄS MER

  3. 2. Beta Cell Function: from Human Genetics to Animal Models

    Författare :Martins Kalis; Diabetes - immunovirologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; animal model; Dicer1; genetics; genetic association; single nucleotide polymorphism; SNP; INS-1E; AAT; FOXP3; beta cell function; insulin secretion; FFAR1; insulin; T2D; glucose; T1D;

    Sammanfattning : Beta cell function is an important factor in the development of both Type 1 (T1D) and Type 2 (T2D) diabetes mellitus. T1D is characterized by a primary defect in insulin secretion due to the immune-mediated beta cell destruction, however, the more common T2D beside insulin resistance also include impaired beta cell function as a consequence to abnormal glucose homeostasis. LÄS MER

  4. 3. Aspects of beta cell and thyroid autoimmunity in children

    Författare :Bengt Lindberg; Pediatrisk endokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatrics; virus; vaccination; type 1 diabetes mellitus; thyroiditis; allergy; autoantibodies; Pediatri;

    Sammanfattning : The two most common autoimmune endocrine diseases in children are autoimmune thyroiditis (AIT) and Type 1 (insulin-dependent) diabetes mellitus (IDDM). Autoantibodies (ab) can be found several years before clinical diagnosis in both diseases. LÄS MER

  5. 4. The Stress Hypothesis : Implications for the induction of diabetes-related autoimmunity in children?

    Författare :Anneli Sepa; Ann Frodi; Johnny Ludvigsson; Gunilla Bohlin; Linköpings universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Psychological stress; parenting stress; attachment security; serious life events; children; attitudes; Type I diabetes; beta-cell autoantibodies; prediction; etiology; Medicine; Medicin;

    Sammanfattning : Background: Second to Finland, Sweden has the world’s highest incidence of type 1 diabetes. Experiences of serious life events have retrospectively been shown to constitute a risk factor for the development of this disease, probably via the biological stress response. LÄS MER

  7. 5. Immunoregulatory differences between adult onset type 1 diabetes and latent autoimmune diabetes in adults (LADA)

    Författare :Magnus Hillman; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endokrinologi; sekretion; diabetologi; diabetology; secreting systems; Isotype class switch; Endocrinology; LADA; Autoantibodies; Autoimmunity; Type 1 diabetes;

    Sammanfattning : Autoimmune diabetes is characterized by cell mediated autoimmunity against insulin producing beta cells in pancreatic islets. Type 1 diabetes is the major cause of diabetes in children and adolescents and is believed to be mediated by a Thl driven destruction of beta cells. LÄS MER