Sökning: "Bcl10"

Hittade 3 avhandlingar innehållade ordet Bcl10.

1. 1. Regulation of activation of NF-κB by Calmodulin in T-lymphocytes

   Författare :Sreenivasa Rao Oruganti; Thomas Grundström; Eva Sverinson; Umeå universitet; []
   Nyckelord :Calcium; Calmodulin; CaMKII; TCR; Bcl10; NF-κB;

   Sammanfattning : Nuclear factor kappa B (NF-kB) is a widely expressed family of transcription factors that are involved in a diverse number of processes. These include inflammation or differentiation, survival or apoptosis, and proliferation or cell cycle arrest. LÄS MER

3. 2. Calmodulin mediated regulation of NF-kappaB in lymphocytes

   Författare :Sofia Edin; Thomas Grundström; Sam Okret; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; calcium; CaM; CaMKII; NF-kappaB; Bc110; immunological synapse; Molecular biology; Molekylärbiologi;

   Sammanfattning : NF-κB transcription factors are regulators of a wide spectrum of genes involved in immune responses and inflammation as well as cellular proliferation and survival. Transcriptionally competent NF-κB dimers are retained in the cytoplasm of resting cells by binding to inhibitors of NF-κB (IκBs). LÄS MER

4. 3. Computational analysis on the effects of variations in T and B cells. Primary immunodeficiencies and cancer neoepitopes

   Författare :Gabriel Ndipagbornchi Teku; Proteinbioinformatik; []
   Nyckelord :Network topology; Network dynamics; network modeling; Network Simulation; T cells; B cells; Neoepitopes; Neoantigens; cancer;

   Sammanfattning : Computational approaches are essential to study the effects of inborn and somatic variations. Results from such studies contribute to better diagnosis and therapies. Primary immunodeficiencies (PIDs) are rare inborn defects of key immune response genes. Somatic variations are main drivers of most cancers. LÄS MER