Sökning: "Bcl-XL"

Visar resultat 16 - 20 av 23 avhandlingar innehållade ordet Bcl-XL.

  1. 16. Ribosomal Proteins in Diamond-Blackfan Anemia : Insights into Failure of Ribosome Function

    Författare :Jitendra Badhai; Niklas Dahl; Anthony Wright; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diamond-Blackfan anemia; RPS19; Ribosomal proteins; Haploinsufficiency; cell cycle; Apoptosis; Erythropoiesis; Medical genetics; Medicinsk genetik; Clinical Genetics; klinisk genetik;

    Sammanfattning : Diamond-Blackfan anemia (DBA) is a severe congenital anemia characterized by a defect in red blood cell production. The disease is associated with growth retardation, malformations, a predisposition for malignant disease and heterozygous mutations in either of the ribosomal protein (RP) genes RPS7, RPS17, RPS19, RPS24, RPL5, RPL11 and RPL35a. LÄS MER

  3. 17. Dendritic cells in immune and gene therapy against cancer

    Författare :Andreas Lundqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dendritic cells; immunotherapy; gene therapy;

    Sammanfattning : Dendritic cells (DC) are extensively used for vaccine therapy due to their superior T cell stimulatory capacity. However, the modest therapeutic effects reported by most clinical trials using DC, together with the rapid developing field of DC biology suggests important considerations for improvement of the clinical outcome. LÄS MER

  4. 18. Studies on the mechanisms of sorafenib-induced cell death

    Författare :Pedram Kharaziha; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In 2008, 26% of all deaths were cancer-related, making this group of diseases the second leading cause of death in the EU countries. Derailment of tyrosine kinase signaling is one important pre-requisite towards tumorigenesis. LÄS MER

  5. 19. Targeting MYC and CDK2 in cancer : impacts on senescence, apoptosis and immune modulation

    Författare :Wesam Bazzar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is a disease in which cells acquire the ability to divide uncontrollably and invade other tissues. An important component of this process is the activation of oncogenes and inactivation of tumor suppressor genes. LÄS MER

  7. 20. The impact of Bcl-2 family members on mast cell survival and apoptosis

    Författare :Maria Ekoff; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mast cells are long-lived effector cells of the immune system perhaps best known for their involvement in allergic diseases. There are several acute and chronic inflammations where mast cell accumulation, activation and release of mediators are important for the initiation and perpetuation of the inflammation. LÄS MER