Sökning: "Bcl-2"

Visar resultat 31 - 35 av 137 avhandlingar innehållade ordet Bcl-2.

  1. 31. Long-wave ultraviolet radiation (UVA1) and visible light : therapeutic and adverse effects in human skin

    Författare :Desiree Wiegleb Edström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ultraviolet-A; visible light; p53; p21WAF-1; bcl-2; CD34; port-wine stains; mycosis fungoides; dye laser; photodynamic therapy.;

    Sammanfattning : We studied the effects of repetitive low-dose UVA1 radiation and visible light in normal sunshielded skin, using immunohistochemical staining for p53, p21WAF-1, bcl-2, Ki67 and cyclin A. An increased expression of Ki67 after UVA1 and visible light were observed as a sign of increased proliferation. LÄS MER

  3. 32. Indicators of apoptosis and proliferation in haematological malignancies : with special reference to drug resistance and prognosis

    Författare :Barbara MacNamara; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acute Myeloid Leukaemia; Non-Hodgkin s Lymphoma Drug Resistance; Predictive Factor; International Prognostic Index; Apoptosis; Proliferation; Telomerase; BCL-2; BAX; p53;

    Sammanfattning : Successful treatment of acute myeloid leukaemia (AML) and high-grade non-Hodgkin's lymphoma (HG- NHL) is hampered by development of drug resistance. A better understanding of mechanisms responsible for drug resistance and the identification of factors that predict response to therapy is essential to improve treatment. LÄS MER

  4. 33. Mechanisms and mediators of apoptosis : with special reference to hematological disorders

    Författare :Bengt Fadeel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :apoptosis; Bcl-2; caspases; chemotherapy; chronic granulomatous disease; familial hemophagocytic lymphohistiocytosis; Fas; homology-based modeling; neutrophils; phosphatidylserine; reactive oxygen species;

    Sammanfattning : Life and death are inextricably entwined. Naturally occurring cell death or apoptosis is essential for the of homeostasis and serves to remove extraneous or dangerous cells in a swift and unobtrusive manner. work has demonstrated that such cell death is genetically regulated and transpires according to evolutionarily conserved pathways. LÄS MER

  5. 34. The antagonistic role of activated oncogenes and apoptosis : studies of n-myc and p53 in lymphoid tumorigenesis

    Författare :Yisong Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MPC; EmyN-myc transgene; J3D T Iymphoma cells; p53; v-m y cretrovirus; bcl-2; Gl cell cycle arrest; apoptosis; HPV 16 E7;

    Sammanfattning : Inactivation of the p53 tumor suppressor gene and activation of proto-oncogenes have been implicated in the initiation and/or progression of a number of neoplasms. In this thesis, the involvement of N-myc gene activation has been studied in mouse plasmacytomagenesis and the role of wild-type (wt)p53 and oncogene activation has been evaluated with particular emphasis on apoptosis. LÄS MER

  7. 35. Kostmann syndrome : a clinical and pathophysiological study

    Författare :Göran Carlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Kostmann syndrome; severe congenital neutropenia; autosomal recessive; periodontitis; antibacterial peptides; LL-3 7; apoptosis; Bcl-2; granulocyte colony-stimulating factor; glycosylation; lenograstim; filgrastim.;

    Sammanfattning : Kostmann syndrome or severe congenital neutropenia (SCN) is a rare disease, usually diagnosed during the first months of life, characterized by extremely low levels of neutrophils in the peripheral blood, a maturational arrest of the myelopoiesis in the bone marrow and severe bacterial infections. The purpose of this project was to improve the understanding of the clinical course and the pathophysiology of autosomal recessive SCN. LÄS MER