Sökning: "Bcl-2 family"
Visar resultat 11 - 15 av 47 avhandlingar innehållade orden Bcl-2 family.
11. The role of the mitochondrial membrane system in apoptosis : the influence of oxidative stress on membranes and their interactions with apoptosis-regulating Bcl-2 proteins
Sammanfattning : Apoptosis is a crucial process in multicellular organisms in sculpting them, especially during embryogenesis. In addition, apoptosis is responsible for the clearance of harmful or damaged cells which can otherwise be detrimental to the organism. LÄS MER
12. Targeting Gb3 and apoptosis-related proteins to overcome cisplatin resistance
Sammanfattning : Background Cisplatin is used for treatment of malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) but treatment with cisplatin often leads to acquired resistance to cisplatin, resulting in poor patient survival. Globotriaosylceramide (Gb3) and multidrug resistance protein 1 (MDR1) have been associated with cisplatin resistance. LÄS MER
13. CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside
Sammanfattning : Immunotherapy for cancer is a young research field progressing at high speed. The first chimera of an antibody and a signaling chain was designed by Zelig Eshhar and was later further developed to enhance existing T cell therapy by combining a single-chain fragment of an antibody with the CD3 zeta chain of the TCR complex. LÄS MER
14. Regulation of Mast Cell Survival
Sammanfattning : Mast cells are long-lived effector cells of importance for both acute and chronic inflammations. Mast cells can be activated in many different ways, leading to the release of inflammatory mediators. In contrast to most other inflammatory cells, activated mast cells have the capacity to recover, regranulate and thereby be activated again. LÄS MER
15. Bax and oxidized phospholipids - a deadly complex : Apoptotic protein-lipid assemblies studied by MAS NMR spectroscopy
Sammanfattning : Mitochondria are renowned for their vital role as cellular powerhouses because they provide ATP via cellular respiration. Additionally, these organelles also play an important role in other physiological processes, such as apoptosis. LÄS MER