Sökning: "Bcl-2 family members"

Visar resultat 11 - 15 av 17 avhandlingar innehållade orden Bcl-2 family members.

  1. 11. Structural studies of proteins in apoptosis and lipid signaling

    Författare :Maria Dolores Herman Moreno; Pär Nordlund; Markus Gruetter; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; proteins; crystal structure; apoptosis; cancer; CoFi-Blot; kinases; lipid signaling; Structural biology; Strukturbiologi; Structural Biology; strukturbiologi;

    Sammanfattning : Signaling pathways control the fate of the cell. For example, they promote cell survival or commit the cell to death (apoptosis) in response to cell injury or developmental stimuli, decisions, which are vital for the proper development and functioning of metazoan. LÄS MER

  3. 12. Effects of interferon on cellular proliferation and apoptosis

    Författare :Olle Sangfelt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :interferon; malignancy; apoptosis; cell cycle;

    Sammanfattning : Interferon (IFN) therapy is today a well-established treatment in many diseases, including various malignancies. How IFN exerts antitumor activity is not known, but several mechanisms have been suggested. LÄS MER

  4. 13. Regulation of the pro-apoptotic protein Bim by T cell receptor triggering in human T cells

    Författare :Elena Sandalova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bim; Apoptosis; Mitochondria; CTLs; AICD; TCR activation;

    Sammanfattning : Bim is a significant pro-apoptotic member of Bcl-2 family of proteins; it is proved to be an important regulator of apoptosis: over the years it has been shown to play a pivotal role for the development and maintenance of homeostasis in many cellular systems and tissues. The Bcl-2 family of proteins is a group of key regulators of the mitochondrial, or intrinsic, pathway of apoptosis. LÄS MER

  5. 14. Tissue Factor Biological Functions : Coagulation Activity in Microparticles and Signaling with Focus On Migration and Apoptosis

    Författare :Mikael Åberg; Agneta Siegbahn; Carl-Henrik Heldin; Teet Velling; Björn Dahlbäck; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue factor; Apoptosis; Migration; Chemotaxis; Simvastatin; Platelet Derived Growth Factor; Cell Signaling; Microparticles; Prostasomes; Trombosis; Coagulation; Prostate Cancer; Breast Cancer; Caspase-3; Caspase-8; NFkappaB; PAR2; Transactivation; Monocytes; Clinical chemistry; Klinisk kemi;

    Sammanfattning : Background: Tissue factor (TF) is a 47 kDa transmembrane glycoprotein known as the main initiator of blood coagulation. TF is over-expressed on many malignant cells and apart from increasing the risk of thrombosis, the presence of TF/FVIIa also promotes the progression of cancer and metastasis by intracellular signaling. LÄS MER

  7. 15. Interaction Between Mycobacterium tuberculosis and Human Neutrophils

    Författare :Nasrin Perskvist; Monica Thelestam; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Mycobacterium tuberculosis, the etiologic agent of tuberculosis, is responsible for more deaths each year than any other single pathogen. Mononuclear phagocytes and T cells are crucially involved in the control and local containment of this infection. Less is known about the contribution of neutrophils to control tuberculosis. LÄS MER