Sökning: "Bax"

Visar resultat 21 - 25 av 75 avhandlingar innehållade ordet Bax.

  1. 21. Regulation of apoptosis in human multiple myeloma

    Författare :Helena Spets; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; apoptosis; multiple myeloma; IL-6; Bcl-2; Fas; dexamethasone; IGF-I; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Multiple myeloma (MM) is a clonal expansion of malignant plasmablasts-plasma cells in the bone marrow. MM is slowly proliferating and an increased resistance to apoptosis may be crucial for the tumor progression. LÄS MER

  3. 22. Apoptotic and necrotic cell death after photothrombotic ring stroke : characterization of a stroke model and its morphological and molecular consequences

    Författare :Xiao-Lei Hu; Per Wester; Klas Blomgren; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cerebral ischemic cell death is a major cause of disability and death among stroke patients. The brain cell demise can occur through apoptosis or necrosis or as a continuum of both. This study aimed at establishing a dual setup of a photothrombotic ring stroke model and exploring its morphological and molecular consequences. LÄS MER

  4. 23. Molecular alterations in colorectal cancer

    Författare :Agneta Jansson; Mef Nilbert; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Colorectal cancer is one of the most common causes to death due to cancer in the world. It is important to understand the molecular mechanisms behind tumour development for both prognostic and therapeutic applications. LÄS MER

  5. 24. Nephroprotective effect of the cardiotonic steroid ouabain

    Författare :Ievgeniia Burlaka; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : It has been shown that Na,K-ATPase (NKA) is a signal transducer. Our group described the anti-apoptotic effect of ouabain to the signaling function of NKA. LÄS MER

  7. 25. Apoptotic signaling in lung carcinoma cells : with focus on mechanisms of radioresistance

    Författare :Jessica Ekedahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In this thesis, IR-induced apoptotic signaling was studied in a panel of lung carcinoma cell lines. The goal was not only to achieve a better understanding of the process, but also to identify possible targets for pharmacological modulation to enhance the efficiency of radiotherapy. LÄS MER