Sökning: "Bax"
Visar resultat 16 - 20 av 75 avhandlingar innehållade ordet Bax.
16. On the pro-apoptotic mechanisms of the antitumor drugs doxorubicin and interferon-alpha
Sammanfattning : Anti-cancer drugs act primarily by inducing apoptosis. However, knowledge of how various substances induce apoptosis is still incomplete, and so is the basis for the great variation in cellular sensitivity to cytotoxic drugs. LÄS MER
17. Cathepsin D released from lysosomes mediates apoptosis
Sammanfattning : Last year (2002), the Nobel Prize in Physiology or Medicine was awarded to three scientists who have conducted pioneer research on programmed cell death. In the human body, more than a thousand billion cells are created every day, and an equal number die, thus programmed cell death, or apoptosis, is an important mechanism for maintaining tissue homeostasis and protecting against disease. LÄS MER
18. Yolk sac morphology and uterine blood flow are associated with fetal outcome in diabetes pregnancy
Sammanfattning : Women with pregestational diabetes have a 3-5 times increased risk of giving birth to malformed babies compared with non-diabetic women. The malformations are likely to be induced before the seventh week of pregnancy, when the yolk sac is partly responsible for the transfer of metabolites to the embryo, and the uterine blood flow to the implantation site determines the net amount of nutrients available to the conceptus. LÄS MER
19. The antagonistic role of activated oncogenes and apoptosis : studies of n-myc and p53 in lymphoid tumorigenesis
Sammanfattning : Inactivation of the p53 tumor suppressor gene and activation of proto-oncogenes have been implicated in the initiation and/or progression of a number of neoplasms. In this thesis, the involvement of N-myc gene activation has been studied in mouse plasmacytomagenesis and the role of wild-type (wt)p53 and oncogene activation has been evaluated with particular emphasis on apoptosis. LÄS MER
20. Modulation of cytochrome c release by mitochondrial redox status and caspase-2
Sammanfattning : The release of cytochrome c is an important event during apoptosis, induced by diverse stimuli. Our laboratory has previously proposed that cytochrome c release occurs via a two-step process, involving the detachment of the hemoprotein from its binding to the inner mitochondrial membrane, followed by its release into the cytosol through pores in the outer mitochondrial membrane - an event that is usually triggered by proapoptotic Bcl-2 family proteins, such as Bid, Bax and Bak. LÄS MER
