Sökning: "Bax"

Visar resultat 11 - 15 av 75 avhandlingar innehållade ordet Bax.

1. 11. Fetal Outcome in Experimental Diabetic Pregnancy

   Författare :Sheller Zabihi; Ulf Eriksson; Michael Welsh; Elisabeth (Lisa) Persson; Uppsala universitet; []
   Nyckelord :Cell biology; Rat; Mouse; TG; KO; Diabetes in Pregnancy; Embryo; Folic acid; Superoxide dismutase; Catalase; Glutathione peroxidase; Vascular endothelial growth factor-A; Folate binding protein-1; Bax; Bcl-2; Caspase-3; P53; Pax-3; Blood flow; Cellbiologi;

   Sammanfattning : Women with pregestational diabetes have a 2-5 fold increased risk of giving birth to malformed babies compared with non-diabetic women. Diabetes-induced oxidative stress in maternal and embryonic tissues has been implicated in the teratogenic process. LÄS MER

3. 12. Apoptosis Regulation via the Mitochondrial Pathway : Membrane Response upon Apoptotic Stimuli

   Författare :Marc-Antoine Sani; Gerhard Grobner; Antoinette Killian; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Apoptosis; BH4 peptide; Bax-α1 peptide; model membrane; cardiolipin; solid phase peptide synthesis; circular dichroism; solid-state nuclear magnetic resonance spectroscopy.; Biophysics; Biofysik;

   Sammanfattning : The aim of this thesis was the investigation of the mitochondrial response mechanisms upon apoptotic stimuli. The specific objectives were the biophysical characterization of membrane dynamics and the specific roles of lipids in the context of apoptotic regulation occurring at the mitochondrion and its complex membrane systems. LÄS MER

4. 13. Indicators of apoptosis and proliferation in haematological malignancies : with special reference to drug resistance and prognosis

   Författare :Barbara MacNamara; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Acute Myeloid Leukaemia; Non-Hodgkin s Lymphoma Drug Resistance; Predictive Factor; International Prognostic Index; Apoptosis; Proliferation; Telomerase; BCL-2; BAX; p53;

   Sammanfattning : Successful treatment of acute myeloid leukaemia (AML) and high-grade non-Hodgkin's lymphoma (HG- NHL) is hampered by development of drug resistance. A better understanding of mechanisms responsible for drug resistance and the identification of factors that predict response to therapy is essential to improve treatment. LÄS MER

5. 14. Studies on the Role of Apoptosis in Kidney Diseases

   Författare :Linnéa Nilsson; Hjalmar Brismar; Anita Aperia; Lena Scott; Fredrik Palm; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apoptosis; diabetic kidney disease; hyperglycemia; mesangial cells; microscopy; ouabain; podocytes; proximal tubule cells; RNA-seq; SGLT; Apoptos; diabetisk njursjukdom; hyperglykemi; mesangiala celler; mikroskopi; ouabain; podocyter; proximala tubuli celler; RNA-seq; SGLT; Biological Physics; Biologisk fysik;

   Sammanfattning : Apoptosis is one of the most common types of cell death. Under physiological conditions, it plays an essential role in removal of damaged and potentially harmful cells. Excessive apoptosis has however been linked to a number of diseases including proteinuric kidney disease and DKD, and is believed to enhance the disease progression. LÄS MER

7. 15. Effects of chemotherapy on bone growth and chondrocyte cell death signaling

   Författare :Farasat Zaman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Glucocorticoids (GCs) are widely used in both children and adults to treat common inflammatory diseases, including asthma, rheumatoid arthritis, ulcerative colitis and Crohn’s disease. However, a multitude of undesired side effects have been reported in patients being treated with GCs, such as osteoporosis, obesity, metabolic disturbances, myopathy and decreased linear bone growth (in children). LÄS MER