Sökning: "Bax protein"

Visar resultat 1 - 5 av 42 avhandlingar innehållade orden Bax protein.

  1. 1. Bax and oxidized phospholipids - a deadly complex : Apoptotic protein-lipid assemblies studied by MAS NMR spectroscopy

    Författare :Artur Dingeldein; Gerhard Gröbner; Mikael Elofsson; Tobias Sparrman; Daniel Topgaard; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; mitochondrial membranes; apoptosis; membrane dynamics and organization; Bcl-2 family proteins; Bax protein; biokemi; Biochemistry;

    Sammanfattning : Mitochondria are renowned for their vital role as cellular powerhouses because they provide ATP via cellular respiration. Additionally, these organelles also play an important role in other physiological processes, such as apoptosis. LÄS MER

  3. 2. Insight into the mitochondrial apoptotic pathway : The interplay of the pro-apoptotic Bax protein with oxidized phospholipids and its counterplayer, the pro-survival Bcl-2 protein

    Författare :Marcus Wallgren; Gerhard Gröbner; Marco Colombini; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; apoptosis; Bax; Bcl-2; CD; cell-free protein synthesis; DSC; membrane; mitochondria; oxidized phospholipids; reconstitution; solid state NMR; biologisk kemi; biological chemistry;

    Sammanfattning : Apoptosis plays a crucial role in multicellular organisms by preserving tissue homeostasis and removing harmful cells. The anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and the pro-apoptotic Bcl-2-associated X protein (Bax) act as major regulators of the mitochondrial apoptotic pathway. LÄS MER

  4. 3. Development of NMR methods for studies of dynamics and structure : applications to motilin, Alzheimer β-peptide and ubiquitin

    Författare :Peter Damberg; Ad Bax; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biophysics; biofysik;

    Sammanfattning : NMR spin relaxation was used to study structure and dynamics of two biologically important peptides.The first case concerns the three-dimensional structure of the 22 amino acid residue peptide hormone motilin in the presence of SDS micelles, which mimic a biomembrane environment. LÄS MER

  5. 4. Fetal Outcome in Experimental Diabetic Pregnancy

    Författare :Sheller Zabihi; Ulf Eriksson; Michael Welsh; Elisabeth (Lisa) Persson; Uppsala universitet; []
    Nyckelord :Cell biology; Rat; Mouse; TG; KO; Diabetes in Pregnancy; Embryo; Folic acid; Superoxide dismutase; Catalase; Glutathione peroxidase; Vascular endothelial growth factor-A; Folate binding protein-1; Bax; Bcl-2; Caspase-3; P53; Pax-3; Blood flow; Cellbiologi;

    Sammanfattning : Women with pregestational diabetes have a 2-5 fold increased risk of giving birth to malformed babies compared with non-diabetic women. Diabetes-induced oxidative stress in maternal and embryonic tissues has been implicated in the teratogenic process. LÄS MER

  7. 5. The role of the mitochondrial membrane system in apoptosis : the influence of oxidative stress on membranes and their interactions with apoptosis-regulating Bcl-2 proteins

    Författare :Martin Lidman; Gerhard Gröbner; Magnus Wolf-Watz; Philip Williamson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bax; Bc-2; apoptosis; mitochondria; membranes; oxidized lipids; NMR; calorimetry; circular dichroism; biokemi; Biochemistry; fysikalisk kemi; Physical Chemistry;

    Sammanfattning : Apoptosis is a crucial process in multicellular organisms in sculpting them, especially during embryogenesis. In addition, apoptosis is responsible for the clearance of harmful or damaged cells which can otherwise be detrimental to the organism. LÄS MER