Sökning: "Basic modelling"

Visar resultat 6 - 10 av 267 avhandlingar innehållade orden Basic modelling.

  1. 6. Modelling of drug-effect on time-varying biomarkers

    Författare :Felix Held; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cortisol; TNFα; hierarchical modelling; turnover model; pharmacokinetic pharmacodynamic modelling; cortisol TNFα hierarchical modelling turnover model pharmacokinetic pharmacodynamic modelling;

    Sammanfattning : Model-based quantification of drug effect is an efficient tool during pre-clinical and clinical phases of drug trials. Mathematical modelling can lead to improved understanding of the underlying biological mechanisms, help in finding shortcomings of experimental design and suggest improvements, or be an effective tool in simulation-based analyses. LÄS MER

  3. 7. Computational Modelling of Structures and Ligands of CYP2C9

    Författare :Lovisa Afzelius; Collen Masimirembwa; Ismael Zamora; Anders Karlén; Marcel de Groot; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; CYP2C9; 3D QSAR; GRID; CYP450; pharmacophore modelling; homology modelling; metabolism; competitive inhibitors; CPCA; molecular dynamics simulations; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; läkemedelskemi;

    Sammanfattning : CYP2C9 is one of our major drug metabolising enzymes and belongs to the cytochrome P450 (CYP) super family. The aim of this thesis was to gain an understanding of the quantitative structure–activity relationships (QSAR) of CYP2C9 substrates and inhibitors. LÄS MER

  4. 8. Mechanism-Based Pharmacokinetic and Pharmacodynamic Modelling of Paclitaxel

    Författare :Anja Henningsson; Mats O. Karlsson; Lena Friberg; Iñaki F. Trocóniz; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Mechanism-based; Modelling; Myelosuppression; Paclitaxel; Cremophor EL; NONMEM; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

    Sammanfattning : Paclitaxel (Taxol®) is now widely used against breast, ovarian and non-small-cell lung cancer. Anticancer agents generally have narrow therapeutic indices, often with myelosuppression (mainly neutropenia) as dose-limiting side effect. LÄS MER

  5. 9. Evolutionary and Pharmacological Studies of NPY and QRFP Receptors

    Författare :Bo Xu; Dan Larhammar; Samuel Svensson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neuropeptide Y; genome duplication; Evolution; vertebrate; Pharmacology; Modelling; Kinetics; Bioinformatik; Bioinformatics; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik; Biologi med inriktning mot evolutionär funktionsgenomik; Biology with specialization in Evolutionary Functional Genomics; Farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Sammanfattning : The neuropeptide Y (NPY) system consists of 3-4 peptides and 4-7 receptors in vertebrates. It has powerful effects on appetite regulation and is involved in many other biological processes including blood pressure regulation, bone formation and anxiety. LÄS MER

  7. 10. Confined Compression of Single Particles : Development of a Novel Triaxial Testing Instrument and Particle-Scale Modelling

    Författare :Henrik Jonsson; Göran Frenning; Göran Alderborn; Abderrahim Michrafy; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Powder compaction; Compression; Single particle; Particle mechanics; Powder mechanics; Confined conditions; Triaxial; Apparatus design; Modelling; Galenisk farmaci; Pharmaceutics;

    Sammanfattning : When predicting the performance of a powder compaction process, assessing the behaviour of the particles comprising the powder bed is of central relevance. Currently, however, no experimental methods are available for mimicking the multiaxial loading conditions imposed on the individual particles in a powder bed during compaction, and such analyses are therefore usually performed in silico. LÄS MER