Sökning: "Basic modelling"

Visar resultat 11 - 15 av 267 avhandlingar innehållade orden Basic modelling.

  1. 11. Heterogeneity of human metabolism in health and disease: a modelling perspective

    Författare :Pouyan Ghaffari Nouran; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer metabolism; fatty acid metabolism; genome-scale metabolic models; community modeling; heterogeneity; lung cancer; amino acids metabolism; gut microbiome;

    Sammanfattning : Metabolism is broadly defined as the sum of biochemical reactions within cells that are involved in maintaining the living state of the organism. Profound importance of metabolism comes from the fact that it is the sole source of energy that allows life to resist to be degraded into entropy. LÄS MER

  3. 12. Modelling Sexual Interactions : Sexual behaviour and the spread of sexually transmitted infections on dynamic networks

    Författare :Disa Hansson; Tom Britton; Fredrik Liljeros; KaYin Leung; Janneke Heijne; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mathematical modelling; Sexually transmitted infections; Egocentric network analysis; Dynamic networks; Sexual behaviour; HIV; Statistical inference; Mathematical Statistics; matematisk statistik;

    Sammanfattning : In this thesis we develop statistical and mathematical models to study different factors of relevance for the spread of sexually transmitted infections (STIs). Two special interest groups for STI interventions are considered: sexually active youths and men who have sex with men (MSM). LÄS MER

  4. 13. Blood-Brain Barrier Transport of Drugs Across Species with the Emphasis on Health, Disease and Modelling

    Författare :Karin Tunblad; Margareta Hammarlund-Udenaes; Niclas Jonsson; Elizabeth CM de Lange; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Blood-brain barrier; Disease; Microdialysis; Modelling; Transport; Pharmacokinetics; NONMEM; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci;

    Sammanfattning : The transport of drugs across the blood-brain barrier (BBB) has been investigated in different species using morphine and morphine-6-glucuronide (M6G) as model compounds. The influence of probenecid on the BBB transport of morphine and M6G was investigated, and the consequences of meningitis and severe brain injury on the concentrations of morphine in the brain were examined. LÄS MER

  5. 14. Similarity-based processes in human multiple-cue judgment : evidence from brain imaging and cognitive modelling

    Författare :Sara Stillesjö; Linnea Karlsson Wirebring; Lars Nyberg; Håkan Nilsson; Alan Sanfey; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; multiple-cue judgment; similarity-based; rule-based; exemplar-based model; fMRI; cognitive modelling;

    Sammanfattning : Background: We often make judgments that require the consideration of several sources of information. For example, a teacher that grades a student´s exam question often integrates multiple sources of information (cues: details provided in the answer) into a single criterion dimension (the grade). LÄS MER

  7. 15. Pharmacometrics to characterize innate immune response and antibacterial treatments

    Författare :Anders Thorsted; Lena E. Friberg; Elisabet I. Nielsen; Mats O. Karlsson; Gauri G. Rao; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; non-linear mixed effects modelling; modelling; pharmacokinetics; pharmacodynamics; pkpd; antibiotics; cefuroxime; piperacillin; phagocytes; lipopolysaccharide; endotoxin; porcine endotoxemia; challenge studies; sepsis; critically ill; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The immune system protects the host against pathogens by distinguishing self from non-self. However, it is most-often disregarded in pharmacokinetic-pharmacodynamic (PKPD) characterization of (new and old) antibiotics. LÄS MER