Sökning: "BRCA1"
Visar resultat 16 - 20 av 58 avhandlingar innehållade ordet BRCA1.
16. Investigation of the genetic basis of familial non-BRCA1/2 breast cancer
Sammanfattning : Breast cancer is the most common female malignancy in the Western world and approximately 510% of all breast cancer cases present with some degree of family history. In the mid-nineties genetic linkage analyses successfully identified two breast cancer predisposing genes, BRCA1 and BRCA2. LÄS MER
17. Hereditary breast/ovarian cancer : implementation of BRCA1 and BRCA2 testing
Sammanfattning : Breast cancer is the most common malignancy among women in the western world. Most cases are sporadic but in 5 to 10 % an inherited genetic mutation is the main cause of the disease. LÄS MER
18. Hereditary Ovarian Cancer mutation frequencies and genetic profiles
Sammanfattning : Ovarian cancer is a leading cause of gynecological cancer death and in Sweden nearly 700 cases are diagnosed annually. Ovarian cancer has one of the highest frequencies of hereditary cancer. LÄS MER
19. Breast cancer in young women. Aspects of heredity and contralateral disease
Sammanfattning : Breast cancer is the most commonly diagnosed cancer among women in Sweden, as well as worldwide. In Sweden, 8,288 women were diagnosed with invasive breast cancer in 2019, out of whom approximately 1.5% were younger than 35 years of age. LÄS MER
20. Treatment of BRCA1/2-associated breast cancer and identification of mutation carriers among breast cancer patients
Sammanfattning : The general aim of the research presented in this thesis was to contribute to the understanding of how breast cancer patients with germline BRCA1/2 mutations should be treated medically and surgically, and furthermore, to characterize the limitations and strengths of different procedures for BRCA testing. In Paper I, the long-term prognosis was assessed in a cohort of early-onset breast cancer patients (n = 221). LÄS MER