Sökning: "BRCA"

Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet BRCA.

1. 1. Genetic studies in familial non-BRCA breast cancer

   Författare :Camilla Wendt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Family history is an important risk factor for breast cancer, the presence of breast cancer in a first degree relative in general nearly doubles the risk and the risk increases with the number of affected relatives. Pathogenic mutations in BRCA1, BRCA2 and other high- and moderate risk-genes account for 25% of the familial risk for breast cancer. LÄS MER

3. 2. The Role of BRCA-1 and Nuclear Receptors in regulation of Neural Stem Cell Proliferation and Differentiation

   Författare :Karin Brännvall; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Internal medicine; Invärtesmedicin;

   Sammanfattning : .... LÄS MER

4. 3. Hereditary Ovarian Cancer mutation frequencies and genetic profiles

   Författare :Susanne Malander; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; array comparative genomic hybridization; MLH1 MLH2 MSh6; HNPCC; Hereditary ovarian cancer; BRCA1 BRCA2; Medicine human and vertebrates ; Medicin människa och djur ;

   Sammanfattning : Ovarian cancer is a leading cause of gynecological cancer death and in Sweden nearly 700 cases are diagnosed annually. Ovarian cancer has one of the highest frequencies of hereditary cancer. LÄS MER

5. 4. Treatment of BRCA1/2-associated breast cancer and identification of mutation carriers among breast cancer patients

   Författare :Martin Nilsson; Tumörmikromiljö; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : The general aim of the research presented in this thesis was to contribute to the understanding of how breast cancer patients with germline BRCA1/2 mutations should be treated medically and surgically, and furthermore, to characterize the limitations and strengths of different procedures for BRCA testing. In Paper I, the long-term prognosis was assessed in a cohort of early-onset breast cancer patients (n = 221). LÄS MER

7. 5. Hormonal Regulation of Neural Stem Cell Proliferation and Fate Determination

   Författare :Karin Brännvall; Dan Lindholm; Sandra Ceccatelli; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Neural stem cell; Proliferation; Fate determination; Hormones; Anabolic androgenic steroids; Neurovetenskap; Neurology; Neurologi;

   Sammanfattning : Stem cells have the capacity for both self renewal, and to form all cell types in the body. Interestingly, so called neural stem cells (NSCs) are found in the adult human brain, which is of significance both out of a developmental perspective and from a clinical point of view. LÄS MER