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Visar resultat 1 - 5 av 49 avhandlingar som matchar ovanstående sökkriterier.
1. Glutathione in the brain. Studies on efflux and possible implications in neurotoxicity
Sammanfattning : Neuronal cell death in acute insults such as stroke, trauma and epilepsy involves overactivation of glutamate receptors, calcium influx and increased formation of potentially toxic reactive oxygen species. Glutathione is a key component in the antioxidant defense system against reactive oxygen species. LÄS MER
2. Development of Methods for Assessing Unbound Drug Exposure in the Brain : In vivo, in vitro and in silico
Sammanfattning : The blood-brain barrier is formed by tightly joined capillary cells with transporter proteins and acts as to regulate the brain concentration of nutrients as well as many drugs. When developing central nervous system drugs it is necessary to measure the unbound drug concentration in the brain, i.e. the unbound brain exposure. LÄS MER
3. N-acetylaspartate in brain - studies on efflux and function
Sammanfattning : N-acetylaspartate (NAA) is an amino acid derivative present in high concentration in the brain. The function of NAA is still unsettled in spite of 50 years of research. The mainly neuronal synthesis and glial breakdown of NAA requires a well regulated neuronal efflux and glial uptake. LÄS MER
4. High-Tc SQUIDs for magnetophysiology - development of a magnetometer system and measurements of evoked fields from hippocampal neurons in vitro
Sammanfattning : This thesis concerns development of a system based on a high-transition-temperature superconducting quantum interference device (high-Tc SQUID) magnetometer. The system has been designed and used for magnetic field recordings from brain slices, i.e. magnetophysiology. LÄS MER
5. PET studies of the serotonin transporter in the human brain
Sammanfattning : The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for examination of neurotransmission systems in the human brain in vivo. LÄS MER