Sökning: "BRAIN SLICES"

Visar resultat 1 - 5 av 43 avhandlingar innehållade orden BRAIN SLICES.

  1. 1. Glutathione in the brain. Studies on efflux and possible implications in neurotoxicity

    Detta är en avhandling från Göteborg

    Författare :Camilla Wallin; Göteborgs universitet.; Gothenburg University.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glutathione; excitotoxicity; hypoxia-ischemia; brain; rat; anoxia-aglycemia; g-glutamyl transpeptidase; glutamate; NMDA; oxidative stress; mitochondria; amino acids;

    Sammanfattning : Neuronal cell death in acute insults such as stroke, trauma and epilepsy involves overactivation of glutamate receptors, calcium influx and increased formation of potentially toxic reactive oxygen species. Glutathione is a key component in the antioxidant defense system against reactive oxygen species. LÄS MER

  2. 2. Development of Methods for Assessing Unbound Drug Exposure in the Brain In vivo, in vitro and in silico

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Markus Fridén; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Drug transport; Tissue distribution; Transporters; Pharmacokinetics; PHARMACY Other pharmacy; FARMACI Övrig farmaci; PHARMACY Biopharmacy; FARMACI Biofarmaci; PHARMACY Pharmaceutical pharmacology; FARMACI Farmaceutisk farmakologi; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : The blood-brain barrier is formed by tightly joined capillary cells with transporter proteins and acts as to regulate the brain concentration of nutrients as well as many drugs. When developing central nervous system drugs it is necessary to measure the unbound drug concentration in the brain, i.e. the unbound brain exposure. LÄS MER

  3. 3. N-acetylaspartate in brain - studies on efflux and function

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mattias Tranberg; Göteborgs universitet.; Gothenburg University.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; N-acetylaspartate; Hippocampal slice cultures; HPLC; NMDA; Excitotoxicity; Volume regulation; Canavan disease;

    Sammanfattning : N-acetylaspartate (NAA) is an amino acid derivative present in high concentration in the brain. The function of NAA is still unsettled in spite of 50 years of research. The mainly neuronal synthesis and glial breakdown of NAA requires a well regulated neuronal efflux and glial uptake. LÄS MER

  4. 4. High-Tc SQUIDs for magnetophysiology - development of a magnetometer system and measurements of evoked fields from hippocampal neurons in vitro

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Per Magnelind; [2006]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neuromagnetism; brain slice; neurophysiology; electrophysiology; hippocampus; biomagnetism; SQUID;

    Sammanfattning : This thesis concerns development of a system based on a high-transition-temperature superconducting quantum interference device (high-Tc SQUID) magnetometer. The system has been designed and used for magnetic field recordings from brain slices, i.e. magnetophysiology. LÄS MER

  5. 5. PET studies of the serotonin transporter in the human brain

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Clinical Neuroscience

    Författare :Johan Lundberg; Karolinska Institutet.; Karolinska Institutet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; positron emission tomography; MADAM; WAY 100635; 5-HTT; 5-HT1A receptors; receptor occupancy; major depressive disorder; citalopram; escitalopram;

    Sammanfattning : The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for examination of neurotransmission systems in the human brain in vivo. LÄS MER