Sökning: "BQ-788"

Hittade 2 avhandlingar innehållade ordet BQ-788.

  1. 1. Endothelin in the pulmonary circulation with special reference to hypoxic pulmonary vasoconstriction

    Författare :Peter Holm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :bosentan; BMS-182874; ; BQ-123; BQ-788; endothelin; endothelium; hypoxia; hypoxic pulmonary vasoconstriction; pulmonary hypertension; receptor antagonism; TBC 11251.;

    Sammanfattning : A number of substances originating from the pulmonary endothelium have recently been found to be involved in the regulation of pulmonary vascular tone. Accumulating evidence suggests that endothelial dysfunction contributes to pulmonary hypertension, an important clinical problem often associated with hypoxemia. LÄS MER

  3. 2. The role of endothelin during myocardial ischaemia and reperfusion : pathophysiological mechanisms and interactions with nitric oxide

    Författare :Adrian T Gonon; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ischaemia; reperfusion injury; myocardium; infarct size; endothelium; endothelin; endothelin receptor; nitric oxide; nitric oxide synthase; polymorphonuclear leukocytes; myeloperoxidase; pig; rat;

    Sammanfattning : Acute myocardial infarction followed by reperfusion results in accelerated necrosis of irreversibly injured myocytes as well as induction of lethal injury to reversibly injured cells. Polymorphonuclear leukocytes (PMNs) are major participants in the reperfusion-initiated inflammation. LÄS MER