Sökning: "BQ-123"

Hittade 4 avhandlingar innehållade ordet BQ-123.

  1. 1. Endothelin in the pulmonary circulation with special reference to hypoxic pulmonary vasoconstriction

    Författare :Peter Holm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :bosentan; BMS-182874; ; BQ-123; BQ-788; endothelin; endothelium; hypoxia; hypoxic pulmonary vasoconstriction; pulmonary hypertension; receptor antagonism; TBC 11251.;

    Sammanfattning : A number of substances originating from the pulmonary endothelium have recently been found to be involved in the regulation of pulmonary vascular tone. Accumulating evidence suggests that endothelial dysfunction contributes to pulmonary hypertension, an important clinical problem often associated with hypoxemia. LÄS MER

  3. 2. The role of endothelin during myocardial ischaemia and reperfusion : pathophysiological mechanisms and interactions with nitric oxide

    Författare :Adrian T Gonon; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ischaemia; reperfusion injury; myocardium; infarct size; endothelium; endothelin; endothelin receptor; nitric oxide; nitric oxide synthase; polymorphonuclear leukocytes; myeloperoxidase; pig; rat;

    Sammanfattning : Acute myocardial infarction followed by reperfusion results in accelerated necrosis of irreversibly injured myocytes as well as induction of lethal injury to reversibly injured cells. Polymorphonuclear leukocytes (PMNs) are major participants in the reperfusion-initiated inflammation. LÄS MER

  4. 3. Acute lung failure induced by tricyclic antidepressants : an experimental evaluation

    Författare :Karin Svens; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ARDS; tricyclic antidepressants; isolated lungs; rat; endothelin; endothelial cells; tight junctions;

    Sammanfattning : The tricyclic antidepressant drugs (TCA) have, over the years, been reported to be able to cause adult respiratory distress syndrome (ARDS)/acute lung injury in connection with overdose, and are currently among the most common cause of self-poisoning. Approximately 10% of all TCA overdose patients develop ARDS, and the treatment of these patients, irrespective of the event causing ARDS, is mainly supportive. LÄS MER

  5. 4. Regulation of vascular tone in myometrial resistance arteries in normal pregnancy and preeclampsia

    Författare :Karolina Kublickiene; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Atrial natriuretic peptide; Blood vessels; Endothelin-l; Endothelin receptors; Myogenic tone; Myometrial Arteries; Preeclampsia; Pregnancy; Nitric oxide; Shear stress; Vascular endothelium; Vascular smooth muscle .;

    Sammanfattning : Background: Normal pregnancy is characterized by the occurrence of substantial vasodilatation. Pressure responsiveness and vascular reactivity to administered vasoconstrictors undergo considerable attenuation. These circulatory changes are essential to maintain adequate oxygen and nutrient delivery to the placenta and thus to the fetus. LÄS MER