Sökning: "BMP4"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet BMP4.

1. 1. Glioblastoma heterogeneity and plasticity : Investigating the roles of BMP4 and SOX2

   Författare :Erika Dalmo; Bengt Westermark; Fredrik J. Swartling; Lene Uhrbom; Ana Martin-Villalba; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; SOX2; BMP4; senescence; plasticity; Oncology; Onkologi; Medicinsk vetenskap; Medical Science; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : The malignant primary brain tumor glioblastoma has a dismal prognosis and is distinguished by its heterogeneous character. Current treatment with surgical resection, radiotherapy and adjuvant chemotherapy with the alkylating agent temozolomide does not provide a cure, but simply prolongs survival by a few months. LÄS MER

3. 2. Bone Morphogenetic Protein 4 regulates white, beige and brown adipose tissue

   Författare :Jenny M Hoffmann; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; BMP4; Browning; WAT; BAT; insulin sensitivity;

   Sammanfattning : Obesity and its associated complications, including Type 2 diabetes, are increasing at an epidemic rate globally. Adipose tissue exerts different functions and is central in energy homeostasis, and it consists of white, beige or brown adipocytes. LÄS MER

4. 3. WISP-2 - A Novel Adipokine Related to Obesity and Insulin resistance

   Författare :John Grünberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipose tissue; BMP4; Canonical WNT pathway; Insulin Resistance; Obesity; PPARγ; Type 2 Diabetes; WISP2;

   Sammanfattning : Type 2 diabetes mellitus (T2D) is increasing worldwide at an epidemic rate and is expected to reach 592 million inflicted individuals by 2035 as compared to 382 million in 2013. Obesity is a major risk factor for insulin resistance, defined as an impaired cellular effect of insulin, and this precedes the development of T2D. LÄS MER

5. 4. Human iris characteristics as biomarkers for personality

   Författare :Mats Larsson; Håkan Stattin; Nancy Pedersen; Richard J. Rose; Örebro universitet; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Personality; iris characteristics crypts pigment dots contraction furrows; candidate genes MITF PAX6 SIX3 LMX1B FOXC1 FOXC2 PITX2 BMP4 OLFM3 MSX1 MSX2; anterior cingulate; genetic correlations; heritability; hemispheric asymmetries; approach-related behaviors; Psychology; Psykologi; Psykologi; Psychology;

   Sammanfattning : This dissertation explains why behavioral genetic research can be better informed by using characteristics in the human iris as biomarkers for personality, and is divided into five parts. Part I gives an introduction to the classical twin method and an overview of the findings that have led most developmental researchers to recognize that the normal variation of personality depends on a complex interplay between genetic and environmental factors. LÄS MER

7. 5. From stem cells to neurons : a BMPy ride

   Författare :Therese Andersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Pinpointing the mechanisms behind the formation of the vertebrate development has been an intriguing and challenging task for researchers for several decades. In the 1980s two independent groups managed to isolate cells from the inner cell mass of a mouse blastocyst and to culture and expand them in vitro, while maintaining their pluripotency. LÄS MER