Sökning: "BMP"

Visar resultat 11 - 15 av 93 avhandlingar innehållade ordet BMP.

  1. 11. Signaling mechanisms underlying neural stem cell differentiation. Implications of BMPs, retinoids, and MAP kinases

    Författare :Roland Faigle; Göteborgs universitet; []
    Nyckelord :neural stem cells; differentiation; BMP; ASK1; p38 MAP kinase; CNTF; retinoic acid;

    Sammanfattning : Introduction: Neural stem cells are proliferating cells, derived from the nervous system with the ability to give rise to neurons, astrocytes, and oligodendrocytes. The molecular events and signaling pathways regulating neural stem cell differentiation are largely unknown. LÄS MER

  3. 12. Transforming growth factor-ß. Signal regulation in health and disease

    Författare :Urban Molander; Göteborgs universitet; []
    Nyckelord :TGF-b; BMP; Smad; signal transduction; LDL; skin tumour; mesangial;

    Sammanfattning : TGF-b superfamily members have been shown to play a pivotal role in multicellular organisms. Knowledge about signal transduction pathways is important in order to understand and cure diseases like cancer where TGF-b´s growth inhibitory signal often are disenabled via mutated or absent signalling components. LÄS MER

  4. 13. Specification of the lens and olfactory placodes and dorsoventral patterning of the telencephalon

    Författare :My Sjödal; Juha Partanen; Umeå universitet; []
    Nyckelord :telencephalon; olfactory; lens; BMP; RA; FGF; Wnt; development; placode; gradient; chick; nervous system; dorsoventral; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

    Sammanfattning : The vertebrate nervous system is a highly complex and intriguing structure with diverse functions. To understand the functional nervous system, we first have to be aware of how it is assembled during development. LÄS MER

  5. 14. Heparan sulfate dependent cell signaling and associated pathophysiology : Implications in tumorigenesis and embryogenesis

    Författare :Tahira Batool; Jin-Ping Li; Aristidis Moustakas; Liliana Schaefer; Ingvar Ferby; Michael Welsh; Anders Malmström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparanase; Glucuronyl-C5 epimerase; Heparan Sulfate; Heparin; Lung Cancer; Cancer cell Singling; TGF-Beta; BMP; VEGF; Notch Signaling; Tumor growth; Metastasis; embryonic development; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : Heparan sulfate proteoglycans (HSPGs) consist of a protein core to which several linear, negatively charged heparan sulfate (HS) chains are covalently attached. HSPGs are expressed on the cell surface and in the extra-cellular matrix (ECM) where they have diverse biological functions, for example co-receptor functions. LÄS MER

  7. 15. Directing stem cells and progenitors towards neuronal differentiation - implications for experimental therapies for Parkinson's disease

    Författare :Anke Brederlau; Göteborgs universitet; []
    Nyckelord :stem cells; Parkinson s disease; progenitors; BMP; ASK1; dopamine;

    Sammanfattning : The insight that stem- and progenitor-cells contribute to replacement of nerve cells in the adult central nervous system is the basis of modern therapies for structural brain repair. Their goal is to protect, support and stimulate endogenous stem cells in areas affected by disease and to replace lost cells by transplanting in vitro generated, tailored nerve cells. LÄS MER