Sökning: "BMP-2"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet BMP-2.

  1. 1. Bone Enhancement with BMP-2 for Safe Clinical Translation

    Författare :Marta Kisiel; Jöns Hilborn; Monica Wiig; Richard Oreffo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bone repair; Bone healing; Bone morhogenetic protein-2; Osteogenesis; Extracelular matrix; Hyaluronan; Animal model; Orthopaedics; Ortopedi; Engineering Science with specialization in Materials Science; Teknisk fysik med inriktning mot materialvetenskap;

    Sammanfattning : Bone morphogenetic protein-2 (BMP-2) is considered a promising adjuvant for the treatment of bone regeneration. However, BMP-2 delivery in a conventional collagen scaffold needs a high dose to achieve an effective outcome. Moreover, such dosage may lead to serious side effects. LÄS MER

  3. 2. On the influence of micro-and macroscopic surface modifications on bone integration of titanium implants

    Författare :Patricia Miranda Burgos; Göteborgs universitet; []
    Nyckelord :titanium; dental implants; surface modification; bone tissue; biomechanics; BMP-2;

    Sammanfattning : Background: Osseointegrated titanium implants are routinely used in clinical denstistry as anchorage units for dental prostheses. Although the overall clinical results are good, there are clinical situations when an optimized implant healing is desirable, for instance in order to shorten healing periods and to allow immediate loading. LÄS MER

  4. 3. Regenerative medicine of the airway cartilage : a morphological and immunohistochemical study with focus on cricoid cartilage defects treated with BMP-2

    Författare :Ion Tcacencu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Larynx; growth factor; wound healing; perichondrium; progenitor cells; osteogenesis; growth plate.;

    Sammanfattning : Background: Cartilage provides flexible support for upper airway. Induction of cartilage healing is required for the success of many surgical interventions in the head and neck that are used as treatments for several diseases, such as subglottic stenosis and tumors of the larynx and thyroid. LÄS MER

  5. 4. New insights into principles of scaffolds design for bone application

    Författare :Hongji Yan; Tim Bowden; Hong Qian; Martijn van Griensven; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chondroitin sulfate; hyaluronic acid; pH; cross-linking chemistry; bone morphogenetic protein; lithium; mesenchymal stem cell; in vivo.; Engineering Science with specialization in Nanotechnology and Functional Materials; Teknisk fysik med inriktning mot nanoteknologi och funktionella material;

    Sammanfattning : This thesis presents deeper insights into bone applicable biomaterials’ design. Poor affinity of BMP-2 towards scaffolds required supra-physiological dose administration. Though molecules containing sulfate could sustain BMP-2 release, side effects occurred due to BMP-2 supra-dose, or these sulfate-containing biomolecules. LÄS MER

  7. 5. Craniofacial bone reconstruction with bone morphogenetic protein-2

    Författare :Ann-Charlott Docherty Skogh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :bone morphogenetic protein;

    Sammanfattning : Bone defects in the craniofacial area are a clinical challenge and can be the result of trauma, tumour resection or congenital malformations. The golden standard for reconstruction is autologous bone grafts, but bone may not always be readily available and donor-site morbidity might follow. LÄS MER