Sökning: "BCL2"

Visar resultat 16 - 20 av 20 avhandlingar innehållade ordet BCL2.

1. 16. Dissecting the roles of viral T-antigens in Merkel cell carcinoma

   Författare :Jiwei Gao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Merkel cell carcinoma (MCC) is a rare but aggressive form of skin malignancy with increasing incidence. Merkel cell polyomavirus (MCPyV) is associated with ~80% of MCCs, and a minority is caused by ultra-violet (UV)-induced DNA damage. The MCPyV T-antigens are major drivers for MCC oncogenesis. LÄS MER

3. 17. Regulation of postnatal neurogenesis and brain angiogenesis by thyroid hormone

   Författare :Jenny Liqun Zhang; Göteborgs universitet; []
   Nyckelord :thyroid hormone; neurogenesis; angiogenesis; SVZ OB; hippocampus; neural stem cells; endothelial cells; astrocytes;

   Sammanfattning : Thyroid hormone (TH), which is secreted by the thyroid gland, exerts significant effects on the central nervous system (CNS), especially during development, so that delayed treatment of perinatal hypothyroidism results in severe cognitive retardation. Continuous postnatal neurogenesis occurs throughout adulthood in the subventricular zone (SVZ) of the lateral ventricle wall and in the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampal formation. LÄS MER

4. 18. Role of DNA repair in class switch recombination and somatic hypermutation

   Författare :Likun Du; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Class switch recombination (CSR) and somatic hypermutation (SHM), occurring in the germinal center, are two important processes for B cell development. Both are initiated by activation-induced cytidine deaminase (AID), through deamination of the C residues in the variable and switch regions of the immunoglobulin locus, resulting in either in single stranded or double stranded DNA breaks. LÄS MER

5. 19. The role of mTor in the pathogenesis of tau-related pathologies in Alzheimer disease

   Författare :Zhi Tang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : An important neurophathological hallmark of Alzheimer disease (AD) is the progressive formation of neurofibrillary tangles composed of aberrant hyperphosphorylated tau aggregates. Evidence from human postmortem AD brains and in vitro and in vivo rapamycin-treated drug models implicated an abnormal accumulation of the mammalian target of rapamycin (mTor) in AD brains. LÄS MER

7. 20. Alternative splicing of interleukin-7

   Författare :Nalini Kumar Vudattu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Alternative splicing of pre-mRNA is the primary source of creating proteome diversity in humans; it is therefore highly relevant to disease and therapy. Alternative splicing has been described for many cytokines and these splice variants appear to function as either agonists or as antagonists of the wildtype cytokine. LÄS MER