Sökning: "BCL-6"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet BCL-6.

1. 1. Molecular Characterization of Diffuse Large B-cell Lymphoma and Aspects of Transformation

   Författare :Mattias Berglund; Gunilla Enblad; Svetlana Lagercrantz; Christer Sundström; Catharina Larsson; Ingemar Ernberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Diffuse large B-cell lymphoma; Hodgkin lymphoma; follicular lymphoma; transformation; comparative genomic hybridization; prognosis; Onkologi; Oncology; Onkologi;

   Sammanfattning : Lymphomas are a heterogeneous group of neoplasias originating from B- or T-lymphocytes. In this thesis, we determined the genetic and immunophenotypic characterization of DLBCL and their prognostic impact. LÄS MER

3. 2. Oncogenic mechanisms of AIDS-related neoplasia in humans and SIV infected monkeys

   Författare :Esmeralda Castaños-Vélez; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :immunosuppression; AIDS; lymphoma; Kaposi s sarcoma; EBV HVMF-1; HHV8; cell proliferation; apoptosis; animal model;

   Sammanfattning : Patients with AIDS or immunosuppressive post-transplant therapy are at high risk to develop Kaposi's sarcoma (KS) and malignant lymphoma that represent clinically lethal complications. Lymphomagenesis in simian immunodeficiency virus (SIV) infected cynomolgus monkeys has been shown to be highly similar to lymphomagenesis in immunosuppressed patients. LÄS MER

4. 3. Associations Between Rheumatoid Arthritis and Malignant Lymphomas

   Författare :Eva Baecklund; Christer Sundström; Anders Ekbom; Roger Hällgren; Tore Kvien; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; rheumatoid arthritis; malignant lymphoma; diffuse large B-cell lymphoma; disease activity; disease modifying anti-rheumatic drug; Epstein-Barr virus; germinal centre-like non-germinal centre-like subtype; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

   Sammanfattning : Patients with rheumatoid arthritis (RA) are at increased risk of developing malignant lymphoma, although details about this association remain unclear. The aims of this thesis were to investigate risk factors for lymphoma in patients with RA and to characterize these lymphomas regarding subtype, presence of Epstein-Barr virus (EBV), clinical manifestations and prognosis. LÄS MER

5. 4. Hodgkin Lymphoma : Studies of Advanced Stages, Relapses and the Relation to Non-Hodgkin Lymphomas

   Författare :Rose-Marie Amini; Volker Diehl; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Hodgkin lymphoma; advanced stages; relapse; p53; EBV; Rb; cell line; Onkologi; Oncology; Onkologi; Oncology; onkologi;

   Sammanfattning : The relationship between Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) is not entirely elucidated and a clonal relation may be present more often than previously believed. Mechanisms of tumour progression and resistance to therapy are poorly understood.Between 1974 and 1994 all individuals in Sweden with both HL and NHL were identified. LÄS MER

7. 5. Diffuse large B-cell lymphoma – studies on immunohistochemical and clinical prognostic factors

   Författare :Sverker Hasselblom; Göteborgs universitet; []
   Nyckelord :DLBCL; prognosis; sex; population-based; apoptosis; Ki-67; CTLs; TIA-1; FOXP3; bcl-2; GCB; p-AKT;

   Sammanfattning : DLBCL, the most common lymphoma entity, is a potentially curable but heterogeneous disease. Most studies concerning therapy and prognostic factors have been performed on selected patient materials. It is important to identify immunohistochemical biomarkers which could add prognostic information to clinical factors. LÄS MER