Sökning: "B Zucker"

Hittade 3 avhandlingar innehållade orden B Zucker.

  1. 1. Structural and biochemical insights into biosynthesis and degradation of N-glycans

    Författare :Tom Reichenbach; Christina Divne; David Drew; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; N-glycan; biosynthesis; degradation; glycosyltransferase; glycoside hydrolase; biofuel; enzyme; membrane protein; Bioteknologi; Biotechnology;

    Sammanfattning : Carbohydrates are a primary energy source for all living organisms, but importantly, they also participate in a number of life-sustaining biological processes, e.g. cell signaling and cell-wall synthesis. The first part of the thesis examines glycosyltransferases that play a crucial role in the biosynthesis of N-glycans. LÄS MER

  3. 2. Fatty acids induce potentially atherogenic changes in extracellular matrix proteoglycans

    Författare :Mariam Rodríguez-Lee; Göteborgs universitet; []
    Nyckelord :proteoglycans; glycosaminoglycans; fatty acids; smooth muscle cells; hepatocytes; LDL binding; remnant clearance; insulin resistance; type 2 diabetes;

    Sammanfattning : Insulin resistance and type 2 diabetes (T2D) are associated with an increased prevalence of atherosclerotic cardiovascular disease (CVD). A key step in the initiation of atherogenesis is retention of low density lipoproteins (LDL) in the intima by chondroitin sulfate (CS)-rich proteoglycans (PG). LÄS MER

  4. 3. Kinase cascades in the regulation of glucose homeostasis

    Författare :Tatiana L Steiler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Skeletal muscle; insulin resistance; T2DM; hyperglycemia; high fat diet; glucose transport; PI3K-; MAPK- and AMPK-signaling pathways; AMPKgamma3;

    Sammanfattning : Therapeutic strategies to treat Type 2 Diabetes Mellitus (T2DM) aim at improving muscle insulin sensitivity by either directly modulating, or bypassing defective insulin signaling. Insulin induces metabolic and gene regulatory responses via PI 3-Kinase (PI3K) and Mitogen-Activated Protein Kinase (MAPK) signaling pathways, respectively. LÄS MER