Sökning: "B Holmberg"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden B Holmberg.

1. 1. Molecular genetics of B- and T-lymphocyte development

   Författare :Ingela Wikström; Dan Holmberg; Inga-Lill Mårtensson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lymphocyte development; Dmu protein; transcription factor; bHLH; E2-2; T cell; B cell; marginal zone; Medical genetics; Medicinsk genetik;

   Sammanfattning : Lymphocytes are essential for the generation of specific immunity. Development of B cells in the bone marrow and T cells in the thymus have several analogous features, and are tightly regulated processes. Even though there is an increasing amount of information concerning lymphopoiesis, a lot of questions remain. LÄS MER

3. 2. The genetic basis of T and B cell contribution to autoimmune diabetes in NOD mice

   Författare :Vinícius Motta; Dan Holmberg; Linda Wicker; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 Diabetes; NOD mouse; CTLA-4; superantigen; T cells; Idd; marginal zone B cells; embryo aggregation chimera; negative selection; Immunogenetics; Immungenetik;

   Sammanfattning : The nonobese diabetic mouse (NOD) is an excellent animal model to study type 1 diabetes. As with some humans, disease in the NOD mouse is effected by a combination of genetic and environmental factors. At least 20 insulin dependent diabetes (Idd) susceptibility loci have been identified so far, both in humans and in the NOD mouse. LÄS MER

4. 3. Ensuring the intended volume is given the intended absorbed dose in radiotherapy: Managing geometric variations and treatment hazards

   Författare :Ola Holmberg; Malmö Medicinsk strålningsfysik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; medical instrumentation; tomography; radiology; Clinical physics; safety; risk; hazard; organ motion; set-up; margins; volume definition; radiotherapy; accuracy; Klinisk fysiologi; radiologi; tomografi; medicinsk instrumentering; Radiopharmaceutical technology; Radiofarmaceutisk teknik;

   Sammanfattning : Methods for ensuring that the intended volume receives the intended absorbed dose in radiotherapy have been investigated. In order to optimise radiation treatment of cancer, geometric variations in the treatment chain need to be controlled. Furthermore, hazards potentially leading to unintended irradiation need to be controlled. LÄS MER

5. 4. Critical noise factors and their relation to annoyance in working environments

   Författare :Kjell Holmberg; Luleå tekniska universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Teknisk akustik; Engineering Acoustics;

   Sammanfattning : Noise is one of the most widespread problems in working environments. Besides the obvious risk of hearing damage and masking of warning signals and speech, the effects on concentration, performance, behaviour and general well-being are serious consequences of annoying noise in the working environment. LÄS MER

7. 5. Reduced ROS production triggers arthritis / The role of T cells in arthritis pathogenesis

   Författare :Jens Holmberg; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Spleen and lymph nodes Inflammation Reactive oxygen species T cells MHC; serology; Immunology; Immunologi; serologi;

   Sammanfattning : The aim of this thesis is to defend a novel mechanism that triggers arthritis susceptibility in both rats and mice through reduced production of reactive oxygen species (ROS), but also to introduce a novel model for chronic relapsing arthritis. Five papers are included, all of which employ animal models for rheumatoid arthritis and one that also uses animal models for multiple sclerosis. LÄS MER