Sökning: "Axonal Injury"

Visar resultat 1 - 5 av 79 avhandlingar innehållade orden Axonal Injury.

  1. 1. Definition of axonal injury tolerances across scales : A computational multiscale approach

    Författare :Annaclaudia Montanino; Svein Kleiven; Alessandra Villa; Xiaogai Li; Kacy Cullen; KTH; []

    Sammanfattning : Traumatic brain injury (TBI) is today regarded as a global health challenge. Revealing how external mechanical loads translate into tissue and cellular damage is necessary, not only for the development of better preventive measures, but also for the definition of treatments that could spare the patients from suffering TBI's devastating consequences. LÄS MER

  2. 2. Clinical Consequences of Axonal Injury in Traumatic Brain Injury

    Författare :Sami Abu Hamdeh; Niklas Marklund; Per Enblad; Lars Hillered; Andreas PhD Unterberg MD; Uppsala universitet; []
    Nyckelord :Traumatic brain injury; diffuse axonal injury; intracranial pressure; magnetic resonance imaging; amyloid-beta; tau; Neurokirurgi; Neurosurgery;

    Sammanfattning : Traumatic brain injury (TBI), mainly caused by road-traffic accidents and falls, is a leading cause of mortality. Survivors often display debilitating motor, sensory and cognitive symptoms, leading to reduced quality of life and a profound economic burden to society. LÄS MER

  3. 3. Phospholipase A2 in nerve injury and axonal outgrowth

    Författare :Marie Hornfelt; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neurology; cell death; apoptosis; leukotrienes; arachidonic acid; M-type receptor; secretory phospholipase A2; cytosolic phospholipase A2; sciatic nerve; dorsal root ganglia; growth cone; axonal outgrowth; nerve injury; peripheral nerve regeneration; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; Animal physiology; Djurfysiologi;

    Sammanfattning : This thesis deals with processes coupled to injury in the peripheral nervous system (PNS), with a general aim to investigate the role of phospholipase A2 (PLA2) enzymes in axonal outgrowth. The axonal outgrowth of dorsal root ganglia (DRG) neurons in vitro was reduced by several different inhibitors of PLA2 activity and enhanced by an activator of this enzyme. LÄS MER

  4. 4. Modelling of Diffuse Brain Injury: Combining Methods to Study Possible Links between Transient Intracranial Pressure and Injury

    Författare :Ulrika Krave; Chalmers University of Technology; []
    Nyckelord :animal model; astrocytosis; diffuse axonal injury; neurofilaments; diffuse brain injury; rotational acceleration; closed head trauma; rabbit; finite element analysis; intracranial pressure; injury mechanisms;

    Sammanfattning : The objectives of this research are the study of sagittal rotational acceleration induced diffuse brain injury mechanisms. Such injuries are common in vehicle accidents in particular; the consequences range from mild to severe symptoms and may lead to persistent neurological dysfunction. LÄS MER

  5. 5. Oligodendrocyte pathology following Traumatic Brain Injury : Experimental and clinical studies

    Författare :Johanna Flygt; Niklas Marklund; Fredrik Piehl; Uppsala universitet; []
    Nyckelord :Traumatic brain injury; oligodendrocytes; oligodendrocyte progenitor cells; interleukin 1-β; central fluid percussion injury; Neurokirurgi; Neurosurgery; Neurokirurgi; Neurosurgery;

    Sammanfattning : Traumatic brain injury (TBI) caused by traffic and fall accidents, sports-related injuries and violence commonly results in life-changing disabilities. Cognitive impairments following TBI may be due to disruption of axons, stretched by the acceleration/deceleration forces of the initial impact, and their surrounding myelin in neuronal networks. LÄS MER