Sökning: "Axel Leppert"

Hittade 1 avhandling innehållade orden Axel Leppert.

1. 1. Molecular basis for chaperone activities of the BRICHOS domain against different types of clumpy clients : a route to prevent amyloid toxicity

   Författare :Axel Leppert; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Protein aggregation is a hallmark of a wide range of human disorders, including Alzheimer’s disease and type II diabetes, and are often associated with imbalances in the cellular protein homeostasis. Molecular chaperones play an important role in modulating proteostasis and thereby counteract toxic consequences of misfolded or aggregated proteins. LÄS MER