Sökning: "Avdelningen för klinisk genetik"
Visar resultat 21 - 25 av 90 avhandlingar innehållade orden Avdelningen för klinisk genetik.
21. Molecular cytogenetic characterization of chromosome aberrations in soft tissue and bone tumors
Sammanfattning : Bone and soft tissue tumors (BSTT) belong to a diverse group of solid tumors of mesenchymal origin, with a large number of histological types affecting individuals of all ages. The general aim of the present thesis (Articles I-V) was to investigate in detail the genetic aberrations in selected subtypes of benign and malignant BSTT. LÄS MER
22. The clinical value of genetic analyses of bone and soft tissue tumors
Sammanfattning : Tumors of bone and soft tissue are common but only constitute 1 % of all malignant tumors. The malignant tumors are often difficult to diagnose due to their rarity and morphological resemblance between subtypes. This makes the diagnostic process challenging. LÄS MER
23. Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis
Sammanfattning : Acute lymphoblastic leukemia (ALL) affects individuals at all ages, with peak incidences in children 50 years. ALL is broadly categorized into B-cell precursor (BCP) and T-cell ALL with specific clinical features associated with outcome. LÄS MER
24. Genetic Predisposition to Sporadic and Familial Multiple Myeloma
Sammanfattning : Multiple Myeloma (MM) is the second most common hematological malignancy. It is defined by an uncontrolled growth of plasma cells, usually in the bone marrow. Clinically it is complicated by hypercalcemia, renal failure, anaemia, and bone pain. LÄS MER
25. Genomic and Transcriptomic Analyses of Osteogenic Tumours of Bone
Sammanfattning : Primary tumours of bone are heterogenous and infrequent neoplasms. Distinguishing between benign, intermediate and malignant entities can in some instances pose a clinical challenge. For some tumour types, there is still much to be learned about the genetic mechanisms that give rise to and drive these tumours forward. LÄS MER