Sökning: "Avdelningen för klinisk genetik"
Visar resultat 11 - 15 av 91 avhandlingar innehållade orden Avdelningen för klinisk genetik.
11. Gene Expression Studies of Hematologic Malignacies
Sammanfattning : The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are characteristic of their primary genetic changes. LÄS MER
12. Cytogenetic studies of primary and metastatic breast cancer
Sammanfattning : A series of primary and metastatic breast carcinomas obtained from female and male patients were cytogenetically analysed. Trisomy 12 was identified as a recurrent and sometimes early event in breast carcinogenesis. LÄS MER
13. Cytogenetic studies of benign breast lesions
Sammanfattning : In the present thesis benign breast lesions of various histologies, i.e. LÄS MER
14. Characterization of somatic mutations in nonneoplastic cells
Sammanfattning : Acquired genetic alterations, of which many are visible on the chromosome level, are believed to be necessary for tumorigenesis, and most tumors display characteristic patterns of recurrent structural and numerical aberrations. However, two of the most frequently occurring chromosome mutations in malignant and benign solid tumors, i.e. LÄS MER
15. Identification and Characterization of Novel Candidate Oncogenes
Sammanfattning : Using computer-assisted sequence homology searches we identified three genes encoding proteins similar to certain fusion partner proteins in cancer. The novel APRIL gene was localized to 15q25 and encodes a protein, containing an acidic amino-acid region similar to that/those of leukemia-associated fusion partner proteins DEK and SET. LÄS MER
