Sökning: "Autoimmune regulator"
Visar resultat 6 - 10 av 38 avhandlingar innehållade orden Autoimmune regulator.
6. Molecular Targets in Autoimmune Polyendocrine Syndrome Type1 and Their Clinical Implications
Sammanfattning : Autoimmune diseases occur when the immune system attacks and destroys healthy body tissue. Autoimmunity is known to cause a wide range of disorders, and is suspected to be responsible for many more. Most autoimmune disorders are chronic and cause severe morbidity for the patients, and are also costly for society. LÄS MER
7. Unveiling the protective mechanisms of NOX2-derived ROS against autoimmune diseases
Sammanfattning : Autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), pose a significant burden on society, affecting a considerable portion of the global population. Both SLE and RA are known to have a strong genetic component, with shared genetic predispositions such as neutrophil cytosolic factor 1 (NCF1), which encodes for a subunit of NADPH oxidase 2 (NOX2) complex. LÄS MER
8. Genetic Variation and Expression of the IRF5 Gene in Autoimmune Diseases
Sammanfattning : The interferon regulatory factor 5 (IRF5) gene encodes a transcription factor that plays an important role in the innate as well as in the cell-mediated immune response. The IRF5 gene has received considerable attention since it was shown to be associated with two autoimmune diseases; systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). LÄS MER
9. The TRIM21/Ro52 E3 ligase and its antibodies in autoimmune disease
Sammanfattning : Patients with the systemic autoimmune diseases systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS) often have autoantibodies against Ro/SSA (composed of the TRIM21/Ro52 and Ro60 antigens) and La/SSB. The biological function of the TRIM21/Ro52 protein itself has remained unknown until its recent description as a tripartite-motif (TRIM) family member and an E3 ligase involved in ubiquitination. LÄS MER
10. Antigen presenting cells in autoimmune diabetes: phenotype, function and modulation by Linomide
Sammanfattning : The aim of this thesis was to better understand the role of antigen presenting cells (APC) in the development of diabetes in the nonobese diabetic (NOD) mouse. We have shown that DC and Mphi that infiltrate the islets of Langerhans produce tumour necrosis factor-a (TNF-a), a cytokine known to contribute to the pathogenesis in the early stages of diabetes development. LÄS MER