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Visar resultat 1 - 5 av 38 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Autoimmune Regulator Deficient Mice, an Animal Model of Autoimmune Polyendocrine Syndrome Type I

    Författare :Signe Hässler; Ola Winqvist; Olle Kämpe; Bertrand Huard; Uppsala universitet; []
    Nyckelord :Molecular medicine; autoimmune regulator; autoimmune polyendocrine syndrome type I; peripheral tolerance; antigen presenting cells; autoimmunity; danger signal; knockout mice; Molekylärmedicin;

    Sammanfattning : Autoimmune diseases develop when the immune system fails to distinguish self from non-self or when the immune system is hypersensitive to endogenous or exogenous danger signals, or when a tissue erroneously sends a danger signal to the immune system. The education of the immune system to distinguish self from non-self is mainly carried out in the thymus and gives rise to central tolerance, whereas the ability to sense a danger or a healthy tissue constitutes peripheral tolerance. LÄS MER

  3. 2. Immune Tolerance Mechanisms in Human Breast Cancer

    Författare :Meliha Mehmeti; Malmö Cancerimmunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Immune tolerance; Toll-like receptors; DAMP; Wnt5a; TAMP; Myeloid-derived suppressor cells; Autoimmune regulator;

    Sammanfattning : .... LÄS MER

  4. 3. The autoimmune regulator : studies of immunological tolerance in mouse and man

    Författare :Emma Lindh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of the work presented in this thesis was to investigate how failure in the mechanisms that regulate self-tolerance can lead to autoimmune disease. In particular, I have studied a key player in immunological tolerance, the autoimmune regulator gene (AIRE). LÄS MER

  5. 4. B cell regulation in autoimmune disease

    Författare :Shan Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Our immune system protects us from both foreign antigens and self-derived autoantigens by sophisticated regulation. During an immune response, the innate and adaptive parts of the immune system closely collaborate at every stage of the response. LÄS MER

  7. 5. The role of CTLA-4 in health and autoimmune disease

    Författare :Katrin Klocke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : FOXP3+ regulatory T (Treg) cells are powerful regulators of the immune system, as shown by the development of multi-organ autoimmunity in mice and men upon loss or dysfunction of these cells. Whilst Treg cells are vital to control normal immune responses, they are also involved in the development of autoimmunity and the failure to combat cancer. LÄS MER