Sökning: "Autoimmune regulator"

Visar resultat 1 - 5 av 32 avhandlingar innehållade orden Autoimmune regulator.

  1. 1. Autoimmune Regulator Deficient Mice, an Animal Model of Autoimmune Polyendocrine Syndrome Type I

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Signe Hässler; Uppsala universitet.; [2006]
    Nyckelord :Molecular medicine; autoimmune regulator; autoimmune polyendocrine syndrome type I; peripheral tolerance; antigen presenting cells; autoimmunity; danger signal; knockout mice; Molekylärmedicin;

    Sammanfattning : Autoimmune diseases develop when the immune system fails to distinguish self from non-self or when the immune system is hypersensitive to endogenous or exogenous danger signals, or when a tissue erroneously sends a danger signal to the immune system. The education of the immune system to distinguish self from non-self is mainly carried out in the thymus and gives rise to central tolerance, whereas the ability to sense a danger or a healthy tissue constitutes peripheral tolerance. LÄS MER

  2. 2. Immune Tolerance Mechanisms in Human Breast Cancer

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Meliha Mehmeti; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Immune tolerance; Toll-like receptors; DAMP; Wnt5a; TAMP; Myeloid-derived suppressor cells; Autoimmune regulator;

    Sammanfattning : .... LÄS MER

  3. 3. The autoimmune regulator : Studies of immunological tolerance in mouse and man

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Medicine

    Författare :Emma Lindh; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The aim of the work presented in this thesis was to investigate how failure in the mechanisms that regulate self-tolerance can lead to autoimmune disease. In particular, I have studied a key player in immunological tolerance, the autoimmune regulator gene (AIRE). LÄS MER

  4. 4. The role of CTLA-4 in health and autoimmune disease

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Medical Biochemistry and Biophysics

    Författare :Katrin Klocke; Karolinska Institutet.; Karolinska Institutet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : FOXP3+ regulatory T (Treg) cells are powerful regulators of the immune system, as shown by the development of multi-organ autoimmunity in mice and men upon loss or dysfunction of these cells. Whilst Treg cells are vital to control normal immune responses, they are also involved in the development of autoimmunity and the failure to combat cancer. LÄS MER

  5. 5. Molecular Targets in Autoimmune Polyendocrine Syndrome Type1 and Their Clinical Implications

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mohammad Alimohammadi; Uppsala universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoimmunity; autoantibodies; endocrinology; parathyroid; hypoparathyroidism; Addison s disease; pulmonary symptoms; NALP; NALP5; NLR; KCNRG; MEDICINE Morphology; cell biology; pathology Pathology Molecular medicine; MEDICIN Morfologi; cellbiologi; patologi Patologi Molekylär medicin;

    Sammanfattning : Autoimmune diseases occur when the immune system attacks and destroys healthy body tissue. Autoimmunity is known to cause a wide range of disorders, and is suspected to be responsible for many more. Most autoimmune disorders are chronic and cause severe morbidity for the patients, and are also costly for society. LÄS MER